中国农业科学院农业信息研究所 中国农学会
Agricultural Information Institute of CAAS China Association of Agricultural Science Societies
En
Ch
中国农业科学院农业信息研究所 中国农学会 主办

AI检索

订阅

返回顶部
当前位置: 首页 > 文章 > 新疆牛源产志贺毒素大肠杆菌耐药性及其ESBLs基因鉴定 畜牧兽医学报 2019 (4) 887-892
Position: Home > Articles > Characterization of Antimicrobial Resistance and Extended-Spectrum β-Lactamase Genes in Bovine Origin Shiga Toxin-producing Escherichia coli in Xinjiang Chinese Journal of Animal and Veterinary Sciences 2019 (4) 887-892

新疆牛源产志贺毒素大肠杆菌耐药性及其ESBLs基因鉴定

作  者：
佟盼盼;马凯琪;刘争辉;谢金鑫;苏红;王栋;孙雪;高姣姣;苏战强
单  位：
新疆农业大学动物医学学院
关键词：
产志贺毒素大肠杆菌;耐药性;食源性致病菌;抗生素;ESBLs
摘  要：
本研究的目的是通过调查新疆地区分离的牛源产志贺毒素大肠杆菌(STEC)的耐药表型和基因型,掌握STEC耐药性的发展和传播规律。本研究对新疆6个地区的牛源(非O157:H7)STEC分离株进行了18种抗生素的药物敏感性试验,并检测菌株中携带的超广谱β-内酰胺酶(ESBLs)基因。结果显示:4.31%STEC表现为多重耐药,1.91%为产ESBLs菌株。检测到的主要ESBLs基因包括bla_(TEM)和bla_(CTX-M)。这是首次在新疆STEC中检测到bla_(TEM)和bla_(CTX-M)。本研究分离出的多数多重耐药STEC属于系统发育A群。多重耐药STEC可能是由非致病性大肠杆菌获得毒性和耐药基因而形成的。抗生素的选择压力可能对细菌在牛肠道中的定植表现出一定竞争优势,从而增加了耐药STEC对食物的污染。
译  名：
Characterization of Antimicrobial Resistance and Extended-Spectrum β-Lactamase Genes in Bovine Origin Shiga Toxin-producing Escherichia coli in Xinjiang
作  者：
TONG Panpan;MA Kaiqi;LIU Zhenghui;XIE Jinxin;SU Hong;WANG Dong;SUN Xue;GAO Jiaojiao;SU Zhanqiang;College of Veterinary Medicine, Xinjiang Agricultural University;
单  位：
TONG Panpan%MA Kaiqi%LIU Zhenghui%XIE Jinxin%SU Hong%WANG Dong%SUN Xue%GAO Jiaojiao%SU Zhanqiang%College of Veterinary Medicine, Xinjiang Agricultural University
关键词：
Shiga toxin-producing Escherichia coli;;drug resistance;;foodborne pathogen;;antimicrobial;;ESBLs
摘  要：
The objective of this study was to investigate the phenotypic and genotypic basis of bovine Shiga toxin-producing Escherichia coli(STEC) from Xinjiang and obtain the evolution and spread of STECs resistance. Susceptibility testing to 18 antimicrobials was performed on bovine(non-O157:H7)STEC isolates from 6 regions of Xinjiang. Meanwhile, the extended spectrum β-lactamases(ESBL) genes were amplified. In this study 4.31% STEC isolates were multidrug resistant to antimicrobials(MDR), and 1.91% were ESBLs-producing strains. The predominant ESBL genes detected were bla_(TEM) and bla_(CTX-M). This is the first report of bla_(TEM) and bla_(CTX-M) in STEC isolates in Xinjiang. Most resistant STECs(91.67%) isolated in this study belong to phylogenetic groups A. These findings suggest that MDR STECs are emerging as a result of nonpathogenic E. coli acquiring virulence and resistance genes. This may convey a certain competitive advantage for the colonization of these STECs in cattle when antimicrobial selective pressures are present, potentially leading to an increase in contamination of food with resistant STECs.

相似文章

导出引用
计量
文章访问数: 13
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊

友情链接Friendly link
农业信息研究所Agricultural information institute 农业智能知识服务平台Agricultural intelligent knowledge service platform 农业学术服务平台Agricultural Knowledge Service System 中国知网CNKI 维普网VIP 万方WANFANG DATA
联系我们Contact us

电话Tell：010-82109652-808

邮箱E-mail：agrijournal@caas.cn

服务Service
关于我们About us 意见建议Opinions and suggest
版权说明Copyright
单位：中国农业科学院农业信息研究所 中国农学会 © 2017中国农业科学院农业信息研究所 ICP备案号：京ICP备09089781号-46