当前位置: 首页 > 文章 > 玉米幼芽提取物对垂体后叶素致家兔心肌缺血的保护作用 安徽农业科学 2007,35 (7) 1945-1947
Position: Home > Articles > Protective Effects of Extract of Maize Plumule on Myocardial Ischemia Induced by Pituitrin in Rabbits Journal of Anhui Agricultural Sciences 2007,35 (7) 1945-1947

玉米幼芽提取物对垂体后叶素致家兔心肌缺血的保护作用

作  者:
魏砚明;欧阳五庆;张黎;王俊;申进宝
单  位:
西北农林科技大学动物科技学院
关键词:
玉米幼芽提取物;心肌缺血;心电图;心肌酶;自由基
摘  要:
采用耳缘静脉注射垂体后叶素(pituitrin,Pit)诱发家兔急性心肌缺血,观察Ⅱ导联心电图心率、S-T段位移及T波波幅;心肌酶(谷草转氨酶、乳酸脱氢酶、肌酸激酶);心肌组织中谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)活性和脂质过氧化物丙二醛(MDA)含量的变化。结果显示,玉米幼芽提取物可减轻垂体后叶素诱发的家兔心电图缺血性改变(心率变缓、S-T段抬高、T波高耸),抑制血清中AST、LDH、CK活性的升高,并可增加缺血心肌组织中GSH-Px和SOD活性,抑制MDA含量升高。结果表明,玉米幼芽提取物对垂体后叶素致家兔心肌缺血有一定的保护作用。
译  名:
Protective Effects of Extract of Maize Plumule on Myocardial Ischemia Induced by Pituitrin in Rabbits
作  者:
WEI Yan-ming et al (College of Animal Science and Technology,Northwest Agriculture and Forestry University,Yangling,Shaanxi 712100)
关键词:
Extract of maize plumule;Myocardial ischemia;Electrocardiogram;Myocardial enzyme;Free radicals
摘  要:
In lab experiment the rabbit acute myocardial ischemia was induced by pituitrin(Pit,2.0 U/kg) injected intravenously.The index of heart rate,the locomotions of T wave and S-T section of lead II electrocardiogram(ECG),myocardial enzyme(AST,LDH,CK),and activities of glutathione peroxidase(GSH-Px) and superoxide dismutase(SOD) and contents of malondiadehyde(MDA) in the myocardium were examined.The results showed that extract of maize plumule reduced the myocardial ischemic injury(slowing of heart rate,run-up of T wave and S-T section),restrained the rise of AST,LDH,CK activities in serum,increased activities of GSH-Px and SOD,and decreased MDA contents in the myocardium.These results demonstrated the extract of maize plumule possessed the protective effects on acute myocardial ischemia induced by Pit.

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