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Position: Home > Articles > Synthesis of Chiral α-Hydroxy Acid Hubei Agricultural Sciences 2011,50 (18) 171-172

手性α-羟基酸的合成

作  者:
葛军英
单  位:
宜春学院应用化学研究所/江西省高校应用化学与化学生物学重点实验室
关键词:
冰片;酯化反应;不对称反应;羟基酸;手性源
摘  要:
以具有旋光活性的冰片为手性源,与丙酮酸在一定条件下进行酯化反应,获得具有旋光活性的丙酮酸冰片酯,然后加入格氏试剂与该酯反应,基团主要从空间位阻较小的一端进攻丙酮酸冰片酯,经过一系列处理后用手性柱分析其产物,得到以不同构型过量的α-羟基酸,其对映体过量值(enantiomer ex-cess value)最高达98%。
译  名:
Synthesis of Chiral α-Hydroxy Acid
作  者:
GE Jun-ying(Key Applied Chemistry and Chemical Biology Laboratory of Jiangxi Province/Institute of Applied Chemistry of Yichun University, Yichun 336000,Jiangxi,China)
关键词:
borneol;esterification;asymmetric reactions;α-hydroxy acid;chiral
摘  要:
A chiral pyruvate bornyl was synthesized by chiral borneol and pyruvate,which then reacted with the grirand reagent that mainly attacking the end of chiral pyruvate bornyl with smaller steric hinder.The product abtained after a series of treatments was analyzed with a chiral column.The results showed that excess α-hydroxy acids with different configuration were obtained and the highest enantiomer excess value reached 98%.

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