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Position: Home > Articles > in vivo Antioxidant Activity and Immune Activity of Sesame Peptides from Solid-State Fermentation FOOD SCIENCE 2014,35 (19) 251-254

发酵芝麻粕小肽体内抗氧化和免疫活性

作  者：
李旸;张莉;陈文帮;钱坤;李吕木;徐雅芫;许发芝;丁小玲
单  位：
安徽农业大学动物科技学院;安徽省畜牧生物工程技术研究中心;安徽省兽药饲料监察所;安徽农业大学茶与食品科技学院
关键词：
发酵芝麻粕;小肽;抗氧化;免疫活性;动物实验
摘  要：
研究从发酵芝麻粕中提取分离出的小肽体内抗氧化和免疫活性。将56只4周龄健康昆明小鼠随机分成7组,分别灌胃生理盐水,低、中、高3个剂量的小肽(三肽和四肽),连续灌胃28d后取血,测定肝脏、脾脏、胸腺系数,血清中丙二醛含量,肝匀浆中的丙二醛含量、超氧化物歧化酶与谷胱甘肽过氧化物酶的活性,脾脏中T淋巴细胞CD3~+、CD4~+和CD8~+数量。灌胃发酵芝麻粕三肽和四肽后,血清和肝脏中丙二醛含量显著下降(P<0.05),肝脏中超氧化物歧化酶和谷胱甘肽过氧化物酶活性显著升高(P<0.05),四肽高剂量组小鼠的CD4~+/CD8~+值显著升高(P<0.05)。结果表明发酵芝麻粕三肽和四肽均具有体内抗氧化能力,四肽在本实验设定中的高剂量条件下能在一定程度上增强机体的免疫活性。
译  名：
in vivo Antioxidant Activity and Immune Activity of Sesame Peptides from Solid-State Fermentation
作  者：
LI Yang;ZHANG Li;CHEN Wen-bang;QIAN Kun;LI Lu-mu;XU Ya-yuan;XU Fa-zhi;DING Xiao-ling;College of Tea and Food Science and Technology,Anhui Agricultural University;Institute of Anhui Animal Feed and Veterinary Drug Control;Anhui Animal Biological Engineering Technology Research Center;College of Animal Science and Technology,Anhui Agricultural University;
关键词：
fermented sesame meal;;peptide;;antioxidant activity;;immune activity;;animal experiments
摘  要：
The antioxidant activity and immune activity of small peptides(tripeptides and tetrapeptides) from fermented sesame meal were investigated in vivo.Totally 56 healthy Kunming mice(4 weeks old) were randomly divided into 7groups.The mice in normal control group were administered with saline,and those in test groups were administered with sesame tripeptides or tetrapeptides at doses of 2,4,and 8 mg/d,respectively.After continuous intragastric admi nistration for 28 days,the mice were sacrificed to harvest serum and liver.The organ coefficients of liver,spleen and thymus,malondialdehyde(MDA) content in serum and liver,and the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px)in liver were determined.T-lymphocytes such as CD3+,CD4+ and CD8+ in spleen were tested by flow cytometer.The results showed that,in mice fed the sesame peptides,the organ coefficients were not changed significantly(P > 0.05),but MDA contents in serum and liver were reduced significantly(P < 0.05).SOD and GSH-Px activities in liver exhibited a significant increase.CD4+/CD8+ ratio was also significantly increased(P < 0.05) in thetetrapeptide high-dose group.Therefore,both tripeptides and tetrapeptides from fermented sesame meal have obvious antioxidant capacity in vivo,and the tetrapeptides can enhance the body's immune activity when administered at high dose.

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