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当前位置: 首页 > 文章 > 喜来芝石中提取的腐植酸与阿司匹林的分子络合物及其表征 腐植酸 2010 (4) 34-39
Position: Home > Articles > Molecular Complexes of Aspirin with Humic Acid Extracted from Shilajit and Their Characterization Humic Acid 2010 (4) 34-39

喜来芝石中提取的腐植酸与阿司匹林的分子络合物及其表征

作  者：
Md.Khalid Anwer;Suraj P.Agarwal;Asgar Ali;Yasmin Sultana;黄静
单  位：
佳米雅综合大学药剂学院;中国腐植酸工业协会
关键词：
阿司匹林;喜来芝石;腐植酸;表征;稳定性;生物药效率
摘  要：
阿司匹林具有退热、消炎、止痛和抗血小板凝集的作用。乙酰水杨酸分子含一个羧基和一个酯基。酯基容易被水解,导致其药效降低,并会对人体产生副作用。本研究的目的是用冻干技术和溶剂挥发技术,以原料的物质的量比为1∶1和1∶2,制备阿司匹林和腐植酸固态络合物。阿司匹林和腐植酸分子间相互作用通过差示扫描量热法(DSC)、X射线衍射(XRD)、傅里叶变换红外光谱学法(FT-IR)和扫描电子显微镜法(SEM)进行研究。用这些技术能清晰表明固态包合络合物的结构。对物质的量比为1∶2冻干络合物研究表明,阿司匹林的稳定性和溶出率显著提高。优选的冻干阿司匹林与腐植酸(1∶2)络合物对抑制鼠爪水肿和抗溃疡作用测得的最低值(0.63±0.10)与单纯的阿司匹林相比,有明显的降低,证明用其治疗具有非常显著的抗炎作用(P<0.05)。
译  名：
Molecular Complexes of Aspirin with Humic Acid Extracted from Shilajit and Their Characterization
作  者：
Md.Khalid Anwer1,Suraj P.Agarwal 1,Asgar Ali 1,Yasmin Sultana 1write,Huang Jing 2translate (1 Department of Pharmaceutics,Jamia Hamdard University,Hamdard Nagar,New Delhi,110062 2 Humic Acid Industry Association,Beijing,100120)
关键词：
Aspirin;Shilajit;humic acid;characterization;stability;bioavailability
摘  要：
Aspirin possesses antipyretic,anti-inflammatory,analgesic and anti-aggregatory activity.The acetylsalicylic acid molecule has a carboxyl group and an ester group.The ester group can be easily hydrolyzed,which reduces the medicinal value and causes side effects on humans.The aim of the present study was to prepare solid complexes between aspirin and humic by lyophilization and solvent evaporation technique in the molar ratio 1:1 and 1:2.Molecular interaction between aspirin and humic acid were studied by DSC,XRD,FT-IR and scanning electron microscopy.This technique clearly demonstrated the existence of solid inclusion complex formation.The lyophilized complex in the molar ratio 1:2 showed enhanced stability and dissolution rates of aspirin significantly.A highly significant(P<0.05)antiinflammatory action of the treatment of optimized freeze dried (1:2) aspirin complex with humic acid was evidenced by inhibition of rat paw edema and anti-ulcerogenic action was measured by lowest score(0.63±0.10) with significant reduction in ulceration as compared to aspirin alone.

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