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Position: Home > Articles > Research on Chemical Constituents of Dahuang Mudan Decoction Journal of Jilin Agricultural University 2009,31 (6) 41-43

中药复方大黄牡丹汤的化学成分研究

作  者:
崔国有;王丽莎;邓旭明;黄开意;王大成
单  位:
吉林大学和平校区门诊部;沈阳药科大学中药学院;吉林大学畜牧兽医学院
关键词:
中药复方;大黄牡丹汤;化学成分;结构鉴定
摘  要:
为阐明大黄牡丹汤的药效作用物质基础,运用色谱学方法对传统兽用大黄牡丹汤方剂全方进行系统分离,并根据理化性质及波谱数据对所分离的化合物进行结构鉴定。从中分离得到5个化合物,分别为ω-羟基大黄素(1)、β-谷甾醇-3 O-β-D-(6′-十七碳酰基)葡萄糖苷(2)、芦荟大黄素-3-(羟甲基)-O-β-D-葡萄糖苷(3)、牡丹酚(4)、芍药苷元(5)。5个化合物均为首次从本方中分离得到。
译  名:
Research on Chemical Constituents of Dahuang Mudan Decoction
作  者:
CUI Guo-you1,WANG Li-sha1,DENG Xu-ming2,HUANG Kai-yi3,WANG Da-cheng21.Hospital Affiliated to Jilin University Heping Section,Changchun 130062,China;2.College of Animal Science and Veterinary Medicine,Jilin University,Changchun 130062,China;3.School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China
关键词:
Chinese herbal formula;Dahuang Mudan decoction;chemical constituent;structure identification
摘  要:
To investigate the chemical constituents of Dahuang Mudan decoction(DHMDT),Silica gel column chromatography and Sephadex LH-20 gel column chromatography were employed for the isolation and purification.The structures were identified on the basis of spectral data and chemical evidence.Five compounds were isolated and identified as follows: ω-hydroxyemodin(1),sitostery-3-O-β-D-glucoside-6′-O-palmitate(2),aloe-emodin-3-(oxymethyl)-O-β-D-glucoside (3), Paeonol(4),paeoniflorigenone(5).All these compounds were isolated from Dahuang Mudan decoction(DHMDT) for the first time.

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