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当前位置: 首页 > 文章 > 胶质瘤中survivin蛋白的表达及其生物学意义 长江大学学报(自科版)农学卷 2007,4 (1) 3-4+13-15+18
Position: Home > Articles > Survivin Expression and its Biological Significance behind Human Gliomas Journal of Yangtze University(Natural Science Edition)Agricultural Science Volumn 2007,4 (1) 3-4+13-15+18

胶质瘤中survivin蛋白的表达及其生物学意义

作  者：
许先平;吴明灿;陈世洁;罗国才
单  位：
长江大学附属第一医院荆州市第一人民医院神经外科;长江大学医学院
关键词：
胶质瘤;survivin蛋白;增殖;凋亡;微血管密度
摘  要：
目的:探讨survivin蛋白在胶质瘤中的表达情况及其与增殖指数、凋亡指数和微血管密度的相关性。方法:采用S-P法检测胶质瘤56例和正常脑组织8例中survivin蛋白、Ki67和FⅧRAg的表达,肿瘤细胞的凋亡采用TUNEL检测,并结合病理特点进行分析。结果:Ⅰ～Ⅱ、Ⅲ、Ⅳ级胶质瘤中,sur-vivin蛋白的表达率分别为25.3%、56.8%、83.2%,组织学分级之间差异有显著性(P<0.05);survivin表达阳性者的Ki67、微血管密度明显高于survivin阴性者,而其凋亡率则低于survivin阴性者,差异有显著性(P<0.05);正常脑组织中未见survivin表达。结论:Survivin在胶质瘤中高表达,与其恶性程度、凋亡、增殖活性及血管生成密切相关。
译  名：
Survivin Expression and its Biological Significance behind Human Gliomas
作  者：
XU Xian-ping(Department of neurosurgery, the first Affiliated Hospital of Yangtze University, Jingzhou 434000, China)WU Min-can(Medical School of Yangtze University , Jingzhou 434000 ,China)CHEN Shi-jie(Department of neurosurgery, the first Affiliated Hospital of Yangtze University, Jingzhou 434000, China) LUO Guo-cai( Medical School of Yangtze University , Jingzhou 434000 ,China)
关键词：
Gliomas; Survivin protein;Proliferation;Apoptosis;MVD
摘  要：
Objective: To explore the relationships of survivin expression with proliferation, apoptosis and angiogenesis of gliomas. Methods: The expressions of survivin, Ki67 and Factor Ⅷ-related antigen (FⅧRag) were detected by immunohistochemistry and Apoptotic cells of tumors were screened by TdT-mediated dUTP nick end-labeling(TUNEL) in the paraffin-embeded sections of 56 gliomas and 8 cases normal brain tissue. Results: Expression of survivin was significantly associated with malignant grade of gliomas.Furthermore, survivin-positive gliomas had higher Ki67 labeling index(LI) and MVD than that of survivin-negative gliomas(P<0.05),and AI was inversely correlated with survivin expression.No survivin expression was detected in the tissue samples from normal brain.Conclusion: In gliomas, survivin overexpression has an extremely close relationship to malignant proliferation, antiapoptosis and angiogenesis of brain gliomas.

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