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当前位置: 首页 > 文章 > ZD制剂对非开放性软组织损伤模型小鼠肌肉中IL-1β表达的影响 畜牧与饲料科学 2016,37 (4) 1-4
Position: Home > Articles > ZD Preparation Inhibits the Inflammation Caused by Closed Soft Tissue Injuries in Mice by Reducing the Expression of IL-1β Animal Husbandry and Feed Science 2016,37 (4) 1-4

ZD制剂对非开放性软组织损伤模型小鼠肌肉中IL-1β表达的影响

作  者：
高鑫;李云章
单  位：
内蒙古农业大学兽医学院
关键词：
ZD制剂;小鼠;软组织损伤;肌肉;免疫组化;IL-1β
摘  要：
旨在评价ZD制剂对非开放性软组织损伤模型小鼠肌肉中IL-1β表达的影响。利用文献报道的方法,制备小鼠非开放性软组织损伤模型。于造模后第2天开始进行给药治疗,正常组和模型组小鼠不给予任何处理。于造模初期和治疗期间观察各组小鼠的精神活动状态及肉眼病理学变化。于造模第2天和第7天,运用免疫组化法检测各组小鼠损伤局部肌肉组织中IL-1β的表达情况。结果表明,模型组小鼠在造模初期出现精神沉郁、跛行等现象,损伤局部的肌肉组织出现肿胀和皮下淤血等现象。治疗后,小鼠肌肉组织病变明显减轻。造模第2天,模型组、阳性药物对照组、ZD制剂治疗组小鼠肌肉组织中的IL-1β表达量显著高于正常组(P<0.05)。造模第7天,阳性药物对照组、ZD制剂治疗组小鼠肌肉组织中的IL-1β表达量显著低于正常组(P<0.05)。综上提示,ZD制剂对小鼠的非开放性软组织损伤具有缓解作用,其作用机理可能与抑制炎性介质的表达有关。
译  名：
ZD Preparation Inhibits the Inflammation Caused by Closed Soft Tissue Injuries in Mice by Reducing the Expression of IL-1β
作  者：
GAO Xin;LI Yun-zhang;College of Veterinary Medicine,Inner Mongolia Agricultural University;
关键词：
ZD preparation;;mice;;soft tissue injuries;;muscle;;immunohistochemistry;;IL-1β
摘  要：
This study was conducted to evaluate the effect of a traditional Chinese medicine compound ZD preparation on the expression of IL-1β in muscle of closed soft tissue injured mice. The soft tissue injured model in mice was prepared by the reported methods. The mice were treated by ZD preparation and positive control drugs at the 2ndday after modeling, but the mice in healthy group and model group received no treatment. The health situation and pathological changes of the mice were observed by naked eyes during the early stage of modeling and therapy. On days of 2 and 7 of modeling, the immunohistochemistry assay was employed to evaluate the expression of IL-1β in the injured muscle tissue. The results showed that the symptoms of depression and claudication were observed in mice of model group, and swelling as well as subcutaneous congestion was also observed in the injured muscle tissue. After treatment, the mice with soft tissue injuries achieved remission of symptoms. At the 2nd day of modeling, the expression of IL-1β in the injured muscle tissue of mice in model group, positive control drugs treatment group and ZD preparation treatment group was significantly higher than that in the normal muscle tissue of mice in healthy group(P<0.05). At the 7~(th) day of modeling, significantly reduced expression of IL-1β in the injured muscle tissue of mice in positive control drugs treatment group and ZD preparation treatment group was found compared with that in the normal muscle tissue of mice in healthy group(P<0.05). The combined data suggests that ZD preparation inhibits the inflammation caused by closed soft tissue injuries in mice by reducing the expression of IL-1β.

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