中国农业科学院农业信息研究所 中国农学会
Agricultural Information Institute of CAAS China Association of Agricultural Science Societies
En
Ch
中国农业科学院农业信息研究所 中国农学会 主办

AI检索

订阅

返回顶部
当前位置: 首页 > 文章 > 艾纳香总黄酮对大鼠皮肤创伤愈合的作用及机制研究 热带农业科学 2017,37 (1) 75-79+83
Position: Home > Articles > The Effect of Total Flavonoids Extracted from Blumea balsamifera(L.) DC. on Skin Wound Healing and Its Mechanism of Rats Chinese Journal of Tropical Agriculture 2017,37 (1) 75-79+83

艾纳香总黄酮对大鼠皮肤创伤愈合的作用及机制研究

作  者：
许罗凤;王丹;庞玉新;杨全;夏奇峰;李小婷;马青松
单  位：
中国热带农业科学院热带作物品种资源研究所;广东药科大学
关键词：
艾纳香;总黄酮;皮肤创伤;IL-1;TNF-α
摘  要：
探讨艾纳香总黄酮对大鼠皮肤创伤愈合的影响及其作用机制。取大鼠150只,随机分为模型组、京万红组和艾纳香总黄酮高、中、低组,建立大鼠背部双侧圆形创伤模型,连续给药10 d,测定创面面积,计算愈合率;于术后的1、3、5、7、10 d检测创缘组织IL-1、TNF-α表达量并切取创伤边缘皮肤全层,制片,HE染色后镜下观察创面组织形态学的改变。结果表明:艾纳香总黄酮随药物剂量的增加而提高创面愈合百分率,缩短愈合时间,创伤早期增强创面IL-1、TNF-α的表达。艾纳香总黄酮促进大鼠皮肤创伤的愈合机制之一可能是增强创伤早期炎症因子的分泌,从而促进创面的修复愈合。
译  名：
The Effect of Total Flavonoids Extracted from Blumea balsamifera(L.) DC. on Skin Wound Healing and Its Mechanism of Rats
作  者：
XU Luofeng;WANG Dan;PANG Yuxin;YANG Quan;XIA Qifeng;LI Xiaoting;MA Qingsong;Guangdong Pharmaceutical University;Tropical crops Genetic Resources Institute,CATAS;Hainan Engineering Research Center for Blumea balsamifera;National Resource Center for Chinese Materia Medica,CACMS;College of Life Science,Guizhou University/Guizhou Key Lab for Chinese Medicinal Plant Materials;
关键词：
Blumea balsamifera(L.) DC.;;Total flavonoids;;Skin wound;;IL-1;;TNF-α
摘  要：
One hundred and fifty Sprague-Dawley rats were selected and divided into five groups:a model control group,a positive control group,three groups of total flavonoids extracted from Blumea balsamifera with different concentrations(high,medium and low) to study the effect of the total flavonoids on their skin wound healing and healing mechanism.The whole layer dorsal skin was removed to establish an acute wound healing model,and the wound rats were treated for consecutive 10 days.The area of wound surface and the rate of wound healing were recorded.The samples of wound healing skin were taken from the rats at 1 d,3 d,5 d,7 d,10 d after wound.The histopathological change of wound skin was examined under the microscope.The results showed that higher concentrations of the total flavonoids promoted the skin wound healing rate and shortened the healing time.The levels of IL-1 and TNF-α of the total flavonoids groups were significantly increased at the early stage of trauma.The total flavonoids encouraged the wound healing by inflammatory secretion

相似文章

导出引用
计量
文章访问数: 9
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊

友情链接Friendly link
农业信息研究所Agricultural information institute 农业智能知识服务平台Agricultural intelligent knowledge service platform 农业学术服务平台Agricultural Knowledge Service System 中国知网CNKI 维普网VIP 万方WANFANG DATA
联系我们Contact us

电话Tell：010-82109652-808

邮箱E-mail：agrijournal@caas.cn

服务Service
关于我们About us 意见建议Opinions and suggest
版权说明Copyright
单位：中国农业科学院农业信息研究所 中国农学会 © 2017中国农业科学院农业信息研究所 ICP备案号：京ICP备09089781号-46