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当前位置: 首页 > 文章 > 组胺受体拮抗剂对低致病性禽流感患鸡血液指标的影响 畜牧与兽医 2017 (2) 98-102
Position: Home > Articles > Effect of histamine receptor antagonists on low pathogenic avian influenza hematology Animal Husbandry & Veterinary Medicine 2017 (2) 98-102

组胺受体拮抗剂对低致病性禽流感患鸡血液指标的影响

作  者：
张楚珺;欧德渊;姚红艳;高登慧
单  位：
贵州大学动物科学学院
关键词：
组胺;受体拮抗剂;低致病性禽流感;血液学;黑脚麻鸡
摘  要：
为了研究组胺受体拮抗剂对低致病性禽流感病毒(LPAIV)感染黑脚麻鸡后的患鸡血液学的影响,探讨组胺受体1(H1)、组胺受体2(H2)在低致病性禽流感发生发展过程中的作用,试验选用120只1日龄黑脚麻鸡,育雏至1月龄后每日早晚分别注射0.4 mL/kg的组胺受体拮抗剂或生理盐水,并通过滴鼻感染禽流感病毒H9N2(107EID50),具体分为4组,阴性组(灭菌生理盐水)、阳性组(灭菌生理盐水+H9N2)、扑尔敏(扑尔敏+H9N2)组和西咪替丁(西咪替丁+H9N2)组,分别在第37、44、51日龄采血,测定血液指标。结果显示:扑尔敏组血液中白细胞数量、淋巴细胞数量在37和51日龄时均极显著(P<0.01)高于西咪替丁组和阳性组;第44日龄阳性组白细胞数量、淋巴细胞数量极显著(P<0.01)高于阴性组和扑尔敏组。37和51日龄时阳性组红细胞数量、血红蛋白浓度、红细胞体积和血小板含量均极显著(P<0.01)低于阴性组和扑尔敏组;44日龄时阳性组红细胞数量、红细胞体积和血红蛋白浓度极显著(P<0.01)低于阴性组和扑尔敏组,而阳性组和西咪替丁组血小板含量极显著(P<0.01)高于阴性组和扑尔敏组。结果表明:扑尔敏能够稳定低致病性禽流感患鸡血液中白细胞数量、淋巴细胞数量、红细胞相关指标和血小板数量,西咪替丁效果不显著。
译  名：
Effect of histamine receptor antagonists on low pathogenic avian influenza hematology
作  者：
ZHANG Chujun;OU Deyuan;YAO Hongyan;GAO Denghui;College of Animal Science,Guizhou University;
关键词：
histamine;;receptor antagonist;;low pathogenic avian influenza;;hematology;;blackfeet pock-maketed chicken
摘  要：
This study is aimed to investigate the influence of HA receptor antagonist on hematologic indexes in blackfeet pock-maketed chicken infected by low pathogenic avian influenza virus(LPAIV).One hundred and twenty one-day-old chickens were fed to one month old and then divided into four groups:positive group,negative group,chlortrimeton group and cimetidine group.After infected nasally by LPAIV H9N2,each group was injected different HA receptor antagonist or saline.Blood was collected and hematologic indexes were measured when the chicken were 37,44 and 51 days old.The results showed the numbers of leukocytes and lymphocytes in the chlorpheniramine group were significantly higher at 37 and 51 days old than those in the cimetidine group and positive group(P<0.01),while their numbers in positive group at 44 days old were significantly higher than those in negative group and chlorpheniramine group(P<0.01).The number of red blood cells,erythrocyte volume,hemoglobin concentration and platelet content were significantly lower(P< 0.01) in positive group than those in negative group and chlorpheniramine group at 37 and 51 days old.At 44 days old,the number of red blood cells,the volume of erythrocytes and hemoglobin concentration in the positive group were significantly lower than those in negative group and chlorpheniramine group(P <0.01),while the platelet contents of the positive group and cimetidine group were significantly higher than those of the negative group and chlorpheniramine group(P<0.01).The results suggested that chlorpheniramine could stabilize the white blood cell and lymphocyte counts,erythrocyte index and platelet count in chickens infected with LPAIV,but the effect of cimetidine was not significant.

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