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当前位置: 首页 > 文章 > 六茜素在猪体内药代动力学研究 畜牧兽医学报 2002,33 (1) 59-62
Position: Home > Articles > Study on Pharmacokinetics of Pyroline in Pigs Chinese Journal of Animal and Veterinary Sciences 2002,33 (1) 59-62

六茜素在猪体内药代动力学研究

作  者：
李剑勇;张继瑜;赵荣材;徐忠赞;李金善;薛飞群;柳军席;苗小楼;杜小丽
单  位：
中国农业科学院兰州畜牧与兽药研究所;中国农业科
关键词：
六茜素;药代动力学;高效液相色谱法
摘  要：
实验猪 5头 ,分别单剂量 (30mg·kg-1)iv、(85mg·kg-1)im六茜素 (Pyroline ,PL)后 ,采用反相HPLC法检测PL的血浆浓度。以香草醛为内标 ,流动相为甲醇 -水 (4 0∶6 0 ) ,流动速度为 0 7ml·min-1,检测波长 2 2 0nm。结果所得的PL血药时程两者都符合二室开放模型 ,它们的药物动力学参数为 :iv ,T1/ 2α=1 5 2min ,T1/ 2 β=6 6 0 5min ,AUC =880 0 7mg·min·L-1;im ,T1/ 2ka=0 37min ,T1/ 2α=3 45min ,T1/ 2 β=76 87min ,AUC =5 70 17mg·min·L-1,Tp=1 5 3min ,Cmax =11 34 μg·ml-1。结果表明 :PL　iv和im给药后 ,其在体内吸收迅速 ,分布快和广 ,消除快 ,而且生物利用度低。
译  名：
Study on Pharmacokinetics of Pyroline in Pigs
作  者：
LI Jian yong,ZHANG Ji yu,ZHAO Rong cai,XU Zhong zan,LI Jin shan,XUE Fei qun (Lanzhou Institute of Animal and Veterinary Pharmaceutics Science, Chinese Academy of Agricultural Sciences,Lanzhou 730050,China)
关键词：
Pyroline;Pharmacokinetics;HPLC
摘  要：
Normal pigs were given PL(pyroline)iv 30 mg·kg -1 and im 85 mg·kg -1 .The concentrations of PL in porcine plasma was determined by an HPLC method developed in our laboratory.A Waters model 480 instrument was used throughout the experiment.Vanillin was used as the internal standard at absorption wavelength of 220 nm.A mixture of methanol and water (40∶60) was used as the mobile phase with a flow rate of 0.7 ml·min -1 ,and YWG C 18 H 37 as stationary phase.The method is simple,sensitive and available for pharmacokinetics studies.Plasma drug concentration time courses of PL after iv and im administration of PL were both found to be fitted to a two Compartment open model and their pharmacokinetic parameters were respectively as follows:iv,T 1/2α =1 52 min,T 1/2β =66 05 min,AUC=880 07 mg·min·L -1 ,im,T 1/2ka =0 37 min,T 1/2α =3 45 min,T 1/2β =76 87 min,AUC=570 17 mg·min·L -1 ,T p=1 53 min,Cmax=11 34 μg·ml -1 .Results show:after pigs were given PL iv and im administration,PL was absorbed immediately,distributed rapidly and widely,eliminated fast.Moreover,bioavailability factor of PL in im adminstration was low,

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