中国农业期刊集成服务平台

当前位置: 首页 > 文章 > 含3-氯-5-三氟甲基吡啶基丙烯腈类化合物的设计、合成及杀螨活性农药 2018 (10) 712-715

Position: Home > Articles > Design, Synthesis and Acaricidal Activity of 3-Chloro-5-trifluoromethylpyridyl Acrylonitrile Derivatives Agrochemicals 2018 (10) 712-715

含3-氯-5-三氟甲基吡啶基丙烯腈类化合物的设计、合成及杀螨活性

作者：

刘连才;许良忠

关键词：

2,3-二氯-5-三氟甲基吡啶;丙烯腈;合成;生物活性

摘要：

[目的]合成一系列新型吡啶丙烯腈类化合物,寻找高生物活性分子。[方法]以2,3-二氯-5-三氟甲基吡啶为起始原料,经取代、脱酯、加成反应合成一系列目标化合物。[结果]合成11个结构新颖的3-氯-5-三氟甲基吡啶基丙烯腈类化合物,经~1H NMR和元素分析手段,确定了目标化合物结构。生物活性测定结果表明:化合物V-1、V-2、V-3、V-6和V-7在质量浓度为100 mg/L时,对朱砂叶螨(T. cinnabarinus)若螨的致死率均高于80%,化合物V-3在10 mg/L时对朱砂叶螨卵螨的致死率为89.6%,略高于对照药剂。[结论]筛选出的高活性化合物具有进一步优化的前景,为此类化合物的进一步研究提供了参考。

译名：

Design, Synthesis and Acaricidal Activity of 3-Chloro-5-trifluoromethylpyridyl Acrylonitrile Derivatives

作者：

LIU Lian-cai;XU Liang-zhong;College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology;

单位：

LIU Lian-cai%XU Liang-zhong%College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology

关键词：

2,3-dichloro-5-trifluoromethylpyridine;;acrylonitrile;;synthesis;;biological activity

摘要：

[Aims] To search high bioactive molecules, a series of novel pyridyl acrylonitrile derivatives were designed.[Methods] A series of target compounds were synthesized by substitution, degreasing and addition reaction using2,3-dichloro-5-trifluoromethylpyridine as raw material. [Results] Eleven novel 3-chloro-5-trifluoromethylpyridyl crylonitrile derivatives were synthesized. The structures of the compounds were determined by ~1H NMR and elemental analysis. Bioassay showed that the lethality rates of target compounds V-1, V-2, V-3, V-6 and V-7 against T.cinnabarinus nymphs were all over 80% at 100 mg/L. When the concentration of compound V-3 was 10 mg/L, the lethality rate of T. cinnabarinus eggs was 89.6%, which was slightly higher than that of control group. [Conclusions] The screened highly active compounds has the prospect of further optimization, providing a basis for further research of such compounds.

相似文章

2,3-二氯-5-三氟甲基吡啶的合成方法评述 [袁其亮, 沈德隆, 卢鑫鑫, 付庆] 现代农药 2006,5 (2) 11-13+19
高效氟吡甲禾灵的合成 [徐强, 王述刚, 刘奎涛] 现代农药 2009 (6) 25-27
2-氨基甲基-3-氯-5-三氟甲基吡啶盐酸盐的合成 [陆阳, 陶京朝, 周志莲, 张志荣] 农药科学与管理 2017,38 (9) 16-21
氟吡菌胺的合成工艺研究 [高玉清, 石强强, 潘炳庆, 耿来红, 徐世栋, 张生芳] 现代农药 2017,16 (1) 26-29
吡氟氯禾灵原药的合成 [叶洪玉, 王红, 桂阳, 宋红梅] 农药 2008,47 (4) 31-32
农药中间体2-氯-5-三氟甲基吡啶的合成 [戴耀] 农药 2023 (6) 401-403

导出引用

计量

文章访问数: 8

HTML全文浏览量: 0

PDF下载量: 0

含3-氯-5-三氟甲基吡啶基丙烯腈类化合物的设计、合成及杀螨活性

相似文章

所属期刊

农药

推荐期刊

农药

现代农药