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Position: Home > Articles > 褪黑素对核苷酸结合寡聚域样受体蛋白3炎性小体的影响及其机制 Chinese Journal of Animal Nutrition 2019 (5) 2069-2075

褪黑素对核苷酸结合寡聚域样受体蛋白3炎性小体的影响及其机制

作  者:
秦春力;吕景智;贺稚非;李洪军
单  位:
西南大学动物科技学院
关键词:
NLRP3炎性小体;褪黑素;机制;炎症疾病
摘  要:
随着畜牧业集约化生产水平的不断提高,动物炎症带来的经济损失逐渐受到重视.细胞表面Toll样受体(TLRs)可以通过活化胞浆内核转录因子-κB(NF-κB),诱导核苷酸结合寡聚域样受体蛋白3(NLRP3)炎性小体表达,加剧炎症反应.本文就NLRP3炎性小体与炎症疾病,褪黑素对TLRs、NF-κB和NLRP3炎性小体的作用以及炎症对动物生产的影响作一综述.
作  者:
QIN Chunli;LYU Jingzhi;HE Zhifei;LI Hongjun;College of Animal Science and Technology,Southwest University;College of Food Science,Southwest University;
关键词:
NLRP3 inflammatory corpuscle;;melatonin;;mechanisms;;inflammatory diseases
摘  要:
With the continuous improvement of intensive production level of animal husbandry,the economic losses caused by animal inflammation have been paid more and more attention. Toll-like receptors on cell surface can induce the expression of nucleotide-binding oligomeric domain-like receptor protein-3 inflammatory corpuscle by activating intracytoplasmic nuclear transcription factor-kappa B,and aggravate the inflammatory response. This article reviews the nucleotide-binding oligomeric receptor protein-3 inflammatory corpuscle and inflammatory diseases,the effects of melatonin on Toll-like receptors,nuclear transcription factor-kappa B and nucleotide-binding oligomeric receptor protein-3 inflammatory corpuscle,and the effects of inflammation on animal production.[Chinese Journal of Animal Nutrition,2019,31( 5) : 2069-2075]

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