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当前位置: 首页 > 文章 > 小分子大豆多肽对小鼠胃黏膜保护作用的研究 食品科学 2011,32 (23) 289-292
Position: Home > Articles > Protective Effects of Low-Molecule-Weight Soybean Polypeptides on Gastric Mucosa in Mice FOOD SCIENCE 2011,32 (23) 289-292

小分子大豆多肽对小鼠胃黏膜保护作用的研究

作  者：
戚颖欣;孟军;曹柏营
单  位：
吉林省通化市食品药品检验所;吉林工程技术师范学院食品工程学院
关键词：
大豆多肽;应激性胃溃疡;胃黏膜;溃疡指数
摘  要：
采用束缚-水浸法和无水乙醇诱导法复制小鼠胃黏膜损伤模型,实验动物各分为6组:正常组、模型组、阳性药物组(雷尼替丁+VE),大豆多肽高、中、低剂量组(分别为7.5、5.0、2.5g/(kg.d),连续给药10d后,处死实验动物,观察溃疡指数,同时测定肝组织MDA含量、血清ALT活性、胃黏膜组织SOD和MDA水平。结果表明:成功建立小鼠胃黏膜损伤模型,与模型组比较,大豆多肽高、中剂量组能明显降低应激性和乙醇诱导胃黏膜损伤小鼠的溃疡指数,以高剂量效果最佳,呈明显的剂量依赖性;同时大豆多肽高、中剂量组可明显降低应激性胃黏膜损伤小鼠肝组织MDA和血清中ALT水平;增强乙醇诱导胃黏膜损伤小鼠胃黏膜组织中SOD活力,降低MDA水平。小分子大豆多肽对小鼠胃黏膜损伤有一定的保护作用。
译  名：
Protective Effects of Low-Molecule-Weight Soybean Polypeptides on Gastric Mucosa in Mice
作  者：
QI Ying-xin1,MENG Jun2,CAO Bai-ying1(1.College of Food Engineering,Jilin Teachers,Institute of Engineering and Technology,Changchun 130052,China; 2.Tonghua Food and Drug Administration of Jilin,Tonghua 134000,China)
关键词：
soybean polypeptide;stress-induced stomach ulcer;gastric mucosa;ulcer index
摘  要：
In this study,we examined the protective effects of low-molecular-weight soybean polypeptides(LMWSPs) against gastric mucosal injury in mice induced by water-immersion restraint stress(WIRS) and anhydrous alcohol,respectively.A total of 60 clean male IRC mice were randomly assigned into 6 groups: normal group,model control group,positive drug control group(ranitidine + VE),and high-,medium-and low-dosage LMWSP groups(administered at the dosages of 7.5,5.0 g/(kg·d) and 2.5 g/(kg·d) once daily for 10 consecutive days,respectively).After the last administration,all the mice were killed to observe ulcer index and assay malondialdehyde(MDA) content in the liver,alanine transaminase(ALT) in the serum,and the levels of MDA and SOD in the gastric mucosa.The results showed that WIRS-induced and anhydrous alcohol-induced gastric mucosal injury models were set up in mice successfully.UI was significantly decreased in the high-and medium-dosage LMWSP and positive drug control groups compared with the model control groups(P <0.01) and the UI-reducing effect of LMWSPs was better at the high dosage and consequently followed a dose-dependent pattern.Meanwhile,both dosages of LMWSPs markedly decreased ALT activity in the liver and serum of mice with WIRS-induced gastric mucosal injury,and increased SOD activity and reduced MDA level in mouse gastric mucosa with anhydrous alcohol-induced injury.Based on these findings,we conclude that LMWSPs can function to protect against gastric mucosal injury in mice.

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