中国农业科学院农业信息研究所 中国农学会
Agricultural Information Institute of CAAS China Association of Agricultural Science Societies
En
Ch
中国农业科学院农业信息研究所 中国农学会 主办

AI检索

订阅

返回顶部
当前位置: 首页 > 文章 > E-cadherin、N-cadherin在乳腺癌中表达变化及意义 石河子大学学报(自然科学版) 2013,31 (4) 473-476
Position: Home > Articles > Expression and Significance of E-cadherin and N-cadherin in Breast Carcinoma Journal of Shihezi University(Natural Science) 2013,31 (4) 473-476

E-cadherin、N-cadherin在乳腺癌中表达变化及意义

作  者：
孙建平;李锋;曹玉文;蒋金芳;万国兴;李文琴
单  位：
石河子大学医学院病理系
关键词：
乳腺癌;EMT;E-cadherin;N-cadherin
摘  要：
为观察乳腺浸润性导管癌中,EMT相关表型分子E-cadherin、N-cadherin蛋白表达变化,探讨EMT与乳腺癌变、分级相关性。采用收集70例乳腺癌组织和20例癌旁正常组织制作组织芯片,应用免疫组化EnVision法检测E-cadherin、N-cadherin蛋白表达。结果显示,乳腺浸润性导管癌E-cadherin阳性表达明显降低,同时N-cadherin阳性表达明显升高,E-cadherin与N-cadherin表达呈显著相关性(r=0.405,P<0.05);乳腺癌高、中、低分化组织中,E-cadherin阳性表达逐渐升高,同时N-cadherin阳性表达逐渐降低。由此可知,乳腺癌细胞存在EMT,EMT参与乳腺癌变过程,并与乳腺癌恶性程度有相关性。
译  名：
Expression and Significance of E-cadherin and N-cadherin in Breast Carcinoma
作  者：
SUN Jianping;LI Feng;CAO Yuwen;JIANG Jinfang;WAN Guoxing;LI Wenqin;Department of Pathology,School of Medicine Shihezi University;
关键词：
breast carcinoma;;EMT;;E-cadherin;;N-cadherin
摘  要：
To detect the EMT phenotype molecule E-cadherin and N-cadherin protein expressions in invasive ductal breast carcinoma,and to investigate the correlation between EMT and breast tumor-genesis and histological grade.E-cadherin and N-cadherin protein expressions were determined by immunohistochemistry envision method in 70 cases of breast cancer and 20 cases of cancer adjacent normal tissue microarray.E-cadherin expression was significantly reduced in invasive ductal breast carcinoma,Simultaneously,N-cadherin expression was significantly increased,and a significant correlation was observed between Ecadherin and N-cadherin,(r=0.405,P<0.05).Ranging from High,medium to low breast cancer differentiation,E-cadherin positive expression was gradually increased,while N-cadherin expression was gradually decreased.EMT in breast cancer cell was involved in breast tumor-genesis and associated with the malignancy of breast carcinoma.

相似文章

导出引用
计量
文章访问数: 10
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊

友情链接Friendly link
农业信息研究所Agricultural information institute 农业智能知识服务平台Agricultural intelligent knowledge service platform 农业学术服务平台Agricultural Knowledge Service System 中国知网CNKI 维普网VIP 万方WANFANG DATA
联系我们Contact us

电话Tell：010-82109652-808

邮箱E-mail：agrijournal@caas.cn

服务Service
关于我们About us 意见建议Opinions and suggest
版权说明Copyright
单位：中国农业科学院农业信息研究所 中国农学会 © 2017中国农业科学院农业信息研究所 ICP备案号：京ICP备09089781号-46