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Position: Home > Articles > Study on Structural Features of POU1F1 Gene and Its Relation with Genetic Diseases Journal of Jilin Agricultural University 2004,26 (3) 334-338

POU1F1基因结构特征及其与遗传性疾病的相关性研究

作  者:
滕勇;杨海明;经荣斌
单  位:
扬州大学动物科学系江苏省动物遗传育种重点实验室
关键词:
垂体转录因子;基因;遗传性疾病;相关性
摘  要:
POU1F1基因是POU基因家族的成员之一,在胚胎分化和生长激素、催乳素、促甲状腺素细胞系的发育中发挥着重要作用。POU1F1基因的突变可以导致垂体的发育不全,并阻碍GH、PRL、TSHβ基因的正常分泌。文中对POU1F1基因的结构特征、功能作用进行了综述,并对不同物种的POU1F1蛋白POUHD、POUSD的氨基酸序列以及核苷酸编码序列的同源性进行了比较。
译  名:
Study on Structural Features of POU1F1 Gene and Its Relation with Genetic Diseases
作  者:
TENG Yong, YANG Hai-ming, JING Rong-bin of Animal science of Yangzhou University, Yangzhou 225009, China)
关键词:
POU1F1; gene; genetic diseases; correlation
摘  要:
POU1F1 gene belongs to the family of POU gene. It plays a critical role in the embryonic differentiation and growth of the somatotropic, lactotropic, and thyrotropic cell lineages. It also has an important effect on the growth of pituitary and the expression of GH?PRL?TSHβ gene. In this paper, we discussed the structural features of POU1F1 gene, the function of POU1F1 gene and homologous comparison of amino acid sequence and nucleotide sequence of POU_(HD) and POU_(SD) among human, mouse, cow and pig POU1F1.

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