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当前位置: 首页 > 文章 > 昆虫多巴胺及其受体的研究进展 昆虫学报 2013,56 (11) 110-126
Position: Home > Articles > Advances in insect dopamine and its receptors Acta Entomologica Sinica 2013,56 (11) 110-126

昆虫多巴胺及其受体的研究进展

作  者：
吴顺凡;徐刚;齐易香;夏仁英;黄佳;叶恭银
单  位：
浙江大学昆虫科学研究所
关键词：
多巴胺;多巴胺受体;G蛋白偶联受体;行为;型变;药理学
摘  要：
多巴胺(dopamine,DA)是脊椎动物和无脊椎动物体内一种重要的生物胺,其参与调控了昆虫的多种生理反应和行为过程,如学习与记忆、认知、性取向、抉择、运动以及型变等。多巴胺主要通过结合特异性的G蛋白偶联受体,即多巴胺受体(dopamine receptors,DARs)来发挥生理作用。本文综述了多巴胺在昆虫中的调控、分布及所参与的生理功能,如多巴胺调控昆虫的交配、发育、嗅觉以及运动行为等,特别对DARs的信号转导、生理功能以及药理学等方面进行了详细评述。昆虫的DARs大致可分为两大类:D1-like DARs和D2-like DARs。D1-like DARs包含有2种亚型,分别为DOP1和DOP2。DOP1仅能偶联胞内cAMP的上升,而DOP2不仅可以起胞内cAMP的上升,还可偶联胞内Ca2+的释放。D2-like DARs仅包含有1种亚型DOP3,其被激活后引起胞内cAMP的降低。DA通过激活不同的DARs可偶联不同的第二信使系统,所产生的下游细胞反应则与昆虫的各种行为相关,而对昆虫DARs的药理学研究将有助于我们开发特异性的杀虫剂用于害虫防治。
译  名：
Advances in insect dopamine and its receptors
作  者：
WU Shun-Fan;XU Gang;QI Yi-Xiang;XIA Ren-Ying;HUANG Jia;YE Gong-Yin;Key Laboratory of Agriculture Entomology,Ministry of Agriculture,Institute of Insect Sciences,Zhejiang University;Key Laboratory of Integrated Management of Crop Disease and Pests,Ministry of Education,Jiangsu Key Laboratory of Pesticide Science,Department of Pesticide Sciences,College of Plant Protection,Nanjing Agricultural University;
关键词：
Dopamine;;dopamine receptors;;G-protein-coupled receptors;;behavior;;phase change;;pharmacology
摘  要：
Dopamine(DA) is an important biogenic amine in invertebrates and vertebrates.It is involved in the regulation of a variety of physiological responses and behavior of insects,such as learning and memory,cognition,sexual orientation,locomotion,phase change,etc.DA exerts its effects by binding to specific dopamine receptors belonging to the superfamily of G protein-coupled receptors.In this review,we summarized the current knowledge on the modulation of DA,its distribution in nervous and non-nervous tissues,and its physiological functions in insects,such as its involvement in modulating insect mating,development,olfaction and locomotion.Especially,the recent progress about signal transduction,physiological roles and pharmacological properties of insect dopamine receptors was reviewed in detail.There are two families of insect dopamine receptors,D1-like and D2-like.D1-like DARs have two subtypes,DOP1 and DOP2.DOP1 upregulates intracellular cAMP in the presence of dopamine.The second group of invertebrate dopamine receptors,DOP2,not only upregulates cAMP levels but also increases Ca2 +levels.The D2-like DARs only have one subtype,DOP3,which downregulates intracellular cAMP in the presence of dopamine.DA-mediated generation of second messengers is associated with changes in cellular response,affecting insect behaviors.Pharmacological characterization of insect dopamine receptors may help us develop new specific insecticides for pest management.

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