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当前位置: 首页 > 文章 > 肿节风有效成分迷迭香酸对哮喘小鼠Th1/Th2型细胞因子水平的影响 黑龙江畜牧兽医 2017 (15) 201-203
Position: Home > Articles > Effects of Zhongjiefeng effective components,rosmarinic acid,on the Th1/Th2 cytokine levels in asthmatic mice Heilongjiang Animal Science and Veterinary Medicine 2017 (15) 201-203

肿节风有效成分迷迭香酸对哮喘小鼠Th1/Th2型细胞因子水平的影响

作  者：
梁正敏;黄丽菊;朱宣霖;徐杨峰;文雪梅;聂海英;何家康
单  位：
广西大学动物科学技术学院
关键词：
肿节风;迷迭香酸;哮喘;Th1/Th2平衡;白细胞介素-4(IL-4);γ干扰素(IFN-γ)
摘  要：
为了探讨肿节风有效成分迷迭香酸对小鼠哮喘模型Th1/Th2细胞因子的调节作用,试验将50只雌性Balb/c小鼠随机分为5组,分别为正常对照组、迷迭香酸单药组、OVA哮喘模型组、迷迭香酸治疗组、地塞米松治疗组,采用ELISA方法对支气管肺泡灌洗液(BALF)中白细胞介素-4(IL-4)、白细胞介素-5(IL-5)、白细胞介素-13(IL-13)和γ干扰素(IFN-γ)水平进行了研究。结果表明:与正常对照组比较,OVA哮喘模型组小鼠BALF中IL-4、IL-5和IL-13水平极显著升高(P<0.01),IFN-γ水平极显著降低(P<0.01),IL-4/IFN-γ比例极显著升高(P<0.01);与OVA哮喘模型组比较,迷迭香酸治疗组和地塞米松治疗组显著抑制了IL-4、IL-5和IL-13水平(P<0.05),显著降低了IL-4/IFN-γ比值(P<0.05)。说明肿节风有效成分迷迭香酸具有抑制哮喘Th2细胞因子和调节免疫平衡的作用。
译  名：
Effects of Zhongjiefeng effective components,rosmarinic acid,on the Th1/Th2 cytokine levels in asthmatic mice
作  者：
LIANG Zhengmin;HUANG Liju;ZHU Xuanlin;XU Yangfeng;WEN Xuemei;NIE Haiying;HE Jiakang;The Institute of Animal Science and Technology of Guangxi University;
关键词：
Zhongjiefeng;;rosmarinic acid;;asthma;;Th1/Th2 balance;;IL-4;;IFN-γ
摘  要：
To explore the effects of Zhongjiefeng effective components,rosmarinic acid,on the regulational function of Th1/Th2 cytokines in asthmatic mice,50 female Balb/c mice were divided into 5 groups randomly and named control group,single rosmarinic acid control group,asthma model group,rosmarinic acid treatment group,dexamethasone treatment group,respectively. Then the levels of IL-4,IL-5,IL-13 and IFN-γ in bronchoalveolar lavage fluid( BALF) were detected by the method of ELISA. The results showed that the levels of IL-4,IL-5 and IL-13 in BALF were significantly increased in asthma model group compared with the normal group( P < 0. 01),while the level of IFN-γ was decreased significantly( P < 0. 01),the IL-4/IFN-γ ratio was significantly increased( P < 0. 01). Compared with the asthma model group,the IL-4,IL-5 and IL-13 concentrations and the ratio of IL-4/IFN-γ were significantly decreased in rosmarinic acid treatment group and dexamethasone treatment group( P < 0. 05). According the results,we concluded that the Zhongjiefeng effective components,rosmarinic acid,has effects on the inhibition of Th2 cytokines and the regulational function of immune balance.

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