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Position: Home > Articles > Inclusion Complexes of Dimethomorph withβ-Cyclodextrin and Its Derivatives Agrochemicals 2016 (2) 104-107

β-环糊精及其衍生物对烯酰吗啉的包合作用

作  者:
李姝静;周自若;张小军
单  位:
北京工商大学理学院;中国农业大学理学院
关键词:
烯酰吗啉;环糊精;包合物;溶解性
摘  要:
[目的]研究β-环糊精及其衍生物对烯酰吗啉的包合作用。[方法]以β-环糊精(β-CD)、羟丙基-β-环糊精(HP-β-CD)、甲基-β-环糊精(Me-β-CD)为主体,制备烯酰吗啉的包合物,通过粉末X射线衍射、热重分析、差示扫描量热法等方法研究环糊精与烯酰吗啉的主客体作用。[结果]β-CD、HP-β-CD及Me-β-CD与烯酰吗啉形成了包合比1∶1的包合物,包合常数分别为910、749、1211 M-1。烯酰吗啉在水中的溶解度及稳定性均得到提高。[结论]研究结果将拓宽烯酰吗啉剂型的开发和应用方向。
译  名:
Inclusion Complexes of Dimethomorph withβ-Cyclodextrin and Its Derivatives
作  者:
LI Shu-jing;ZHOU Zi-ruo;ZHANG Xiao-jun;Department of Chemistry, School of Science, Beijing Technology and Business University;Sino-Agri Leading Biosciences Co., Ltd.;
关键词:
dimethomorph;;cyclodextrin;;inclusion complex;;solubility
摘  要:
[Aims] The inclusion complexes of dimethomorph with β-cyclodextrin and its derivatives were investigated.[Methods] The inclusion complexes contain dimethomorph and β-cyclodextrin(β-CD),(2-hydroxy)propyl-β-cyclodextrin(HP-β-CD), methylated-β-cyclodextrin(Me-β-CD) were prepared by freeze-drying method. The effects of inclusion behavior of dimethomorph with β-CD, HP-β-CD, and Me-β-CD were investigated by X-ray diffraction(XRD),thermogravimetric analysis(TG), differential scanning calorimetry(DSC) and scanning electron microscopy(SEM).[Results] The results showed that dimethomorph formed 1∶1 stoichiometric inclusion complex with β-CD, HP-β-CD and Me-β-CD. The apparent stability constant of dimethomorph with β-CD, HP-β-CD and Me-β-CD were 910, 749 and 1211 M-1, respectively. Additionally, the solubility and decomposition temperature of dimethomorph were increased. [Conclusions] Therefore, it can be a potentially promising way to promote its agrochemicals.

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