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Position: Home > Articles > A Review of the Synthesis of Mefentrifluconazole Agrochemicals 2019,58 (7) 475-477,486

氯氟醚菌唑合成方法综述

作  者:
张晓光;王伦;毛明珍;王威;宁斌科
单  位:
西安近代化学研究所氟氮化工资源高效开发与利用国家重点实验室
关键词:
氯氟醚菌唑;杀菌剂;合成
摘  要:
综述了杀菌剂氯氟醚菌唑的合成工艺路线,其中路线1以2-溴--4-氟-三氟甲苯为起始原料经醚化、酰化、环氧化和开环取代4步反应得到目标产物;路线2以2-碘-4-溴-三氟甲苯为起始原料经酰化、环氧化、取代等6步反应制备氯氟醚菌唑原药.
译  名:
A Review of the Synthesis of Mefentrifluconazole
作  者:
ZHANG Xiao-guang;WANG Lun;MAO Ming-zhen;WANG Wei;NING Bin-ke;State Key Laboratory of Fluorine & Nitrogen Chemicals,Xi'an Modern Chemistry Research Institute;
关键词:
mefentrifluconazole;;fungicide;;synthesis
摘  要:
The synthesis routes of mefentrifluconazole were summarized.The route one was prepared from 2-bromo-4-fluorobenzotrifluoride as raw material via reactions of etherification,acylation,epoxidation and ring-opening,etc.The route two was synthesized by using 4-bromo-2-iodo-1-(trifluoromethyl)benzene as primal raw material via acylation,epoxidation,substitution,etc.

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