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当前位置: 首页 > 文章 > 魔芋葡甘露聚糖对小鼠盲肠内分泌短链脂肪酸水平的影响 食品科学 2014,35 (19) 214-219
Position: Home > Articles > Effect of Konjac Glucomannans on Short-Chain Fatty Acids in Cecal Contents of Mice FOOD SCIENCE 2014,35 (19) 214-219

魔芋葡甘露聚糖对小鼠盲肠内分泌短链脂肪酸水平的影响

作  者：
魏秀秀;陈庆森;阎亚丽;赵培
单  位：
天津商业大学生物技术与食品科学学院,天津市食品生物技术重点实验室;天津商业大学生物技术与食品科学学院
关键词：
魔芋葡甘露聚糖;短链脂肪酸;肠道发酵;丁酸
摘  要：
目的:研究魔芋葡甘露聚糖(konjacglucomannans,KGM)对小鼠盲肠中短链脂肪酸(short-chain fatty acids,SOFA)产生量的影响,为开发具有维护肠道健康的功能性食品提供科学依据。方法:选用7周龄BALB/c雄性小鼠40只,随机分为4组,每组10只。分别饲养添加不同剂量KGM(0、25、50、75g/kg)的AIN93纯化饲料,4周后将小鼠拉颈处死,解剖收集盲肠内容物。利用气相色谱法测定样品中SCFA的种类及含量,以确定合适的KGM添加剂量。结果:不同剂量的KGM对小鼠盲肠中SCFA的产生的影响有较大差异。中剂量KGM(50g/kg)对乙酸、丙酸、丁酸的产生均有极显著性的促进作用(P<0.01),低剂量KGM(25g/kg)对乙酸、丁酸的产生有显著性促进作用(P<0.05),高剂量KGM(75g/kg)对乙酸的产生有促进作用(P<0,05),而对丙酸的产生有明显的抑制作用(P<0.05),不同剂量的KGM对异丁酸的产生均无明显促进或抑制作用。结论:中剂量KGM(50g/kg)、低剂量(25g/kg)对BALB/c雄性小鼠具有较好的肠道益生元的功效以及预防和治疗相关肠道疾病的潜能,中剂量KGM最佳。
译  名：
Effect of Konjac Glucomannans on Short-Chain Fatty Acids in Cecal Contents of Mice
作  者：
WEI Xiu-xiu;CHEN Qing-sen;YAN Ya-li;ZHAO Pei;Tianjin Key Laboratory of Food Biotechnology,College of Biotechnology and Food Science,Tianjin University of Commerce;
关键词：
konjac glucomannan;;short-chain fatty acids;;enteric fermentation;;butyric acid
摘  要：
Purpose:To study the effect of konjac glucomannan on short-chain fatty acids in the cecal contents of mice so as to provide a scientific basis for the development of functional foods with intestinal health maintenance.Methods:Forty seven-week-old BALB/c male mice were randomly divided into four groups:control,and KGM low-,moderate-and highdose groups with 10 mice in each group.The mice were fed with AIN93 purified feed plus different doses of KGM(0,25,50,and 75 g/kg).The mice were sacrificed by cervical dislocation after4 weeks and their cecal contents were dissected and collected.Gas chromatography was used to determinate the types and contents of short-chain fatty acids.The suitable dose of KGM for dietary supplementation was then determined.Results:Different doses of KGM exerted considerably different effects on short-chain fatty acids in mouse cecum.Moderate-dose KGM(50 g/kg) significantly(P < 0.01) promoted the production of acetic acid,propionic acid,and butyric acid;low-dose KGM(25 g/kg) significantly promoted the production of acetic acid and butyric acid(P < 0.05);high-dose KGM(75 g/kg) not only significantly promoted the production of acetic acid(P < 0.05) but also significantly inhibited the generation of propionic acid(P < 0.05).Different doses of KGM neither promoted nor inhibited the production of isobutyric acid.Conclusion:Moderate-dose KGM(50 g/kg) and low-dose KGM(25 g/kg) have a good intestinal prebiotic effect on BALB/c male mice and the potential of preventing and treating intestinal disease.

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