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Position: Home > Articles > Study on the correlation between the compound anesthetic for deer anesthesia and the partial ATPase in the cerebral cortex of Rats Heilongjiang Animal Science and Veterinary Medicine 2016 (4) 124-126

鹿复合麻醉剂麻醉与大脑皮质部分ATP酶相关性研究

作者：

王楠;付连军;冯雪;林博;常乃元;李京乘;李闻轩;尹柏双

单位：

吉林农业科技学院动物科技学院

关键词：

鹿复合麻醉剂;鹿;大脑皮质;Na+-K+-ATP酶;Ca2+-Mg2+-ATP酶

摘要：

为了探究鹿复合麻醉剂麻醉与脑区突触体ATP酶相关性,试验选取纯种SD大鼠32只,随机分为对照组、诱导组、麻醉组和催醒组,利用比色法测定样本中ATP酶活性。结果表明:药物作用后大鼠麻醉全程大脑皮质突触体Na~+-K~+-ATP和Mg~(2+)-ATP酶活性诱导组显著降低(P<0.05),麻醉组和催醒组极显著降低(P<0.01)。说明大脑皮质突触体Na~+-K~+-ATP和Mg~(2+)-ATP酶活性的抑制与鹿复合麻醉剂引起麻醉作用具有一定相关性。

译名：

Study on the correlation between the compound anesthetic for deer anesthesia and the partial ATPase in the cerebral cortex of Rats

作者：

WANG Nan;FU Lianjun;FENG Xue;LIN Bo;CHANG Naiyuan;LI Jingcheng;LI Wenxuan;YIN Baishuang;College of Animal Science and Technology,Jilin Agricultural Science and Technology University;

关键词：

compound anesthetic for deer;;deer;;cerebral cortex;;Na+-K+-ATPase;;Ca2+-Mg2+-ATPase

摘要：

To investigate the correlation between the compound anesthetic for deer anesthesia and ATPase in brain synaptosomes,32 pure-bred SD rats were randomly divided into a control group,an induction group,an anesthesia group,and a wake group.The activity of ATPase in the samples was determined using colorimetric assay.The results showed that the activities of Na~+- K~+- ATPase and Mg~(2+)- ATPase from synaptosomes in the cerebral cortex of rats during anesthesia after administration in the induction group were significantly decreased(P<0.05),which were highly significantly decreased(P<0.01) in the anesthesia group and the wake group.The results indicate that the inhibition of the activities of Na~+- K~+- ATPase and Mg~(2+)-ATPase from synaptosomes in the cerebral cortex has a certain correlation with the anesthesia effect of the compound anesthetic for deer.

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鹿复合麻醉剂麻醉与大脑皮质部分ATP酶相关性研究

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