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当前位置: 首页 > 文章 > 瘦素影响强直性脊柱炎Th17相关细胞因子表达的研究 扬州大学学报(农业与生命科学版) 2010,31 (4) 45-49
Position: Home > Articles > The effect of leptin on the Th17 correlated cytokine in ankylosing spondylitis Journal of Yangzhou University(Agricultural and Life Science Edition) 2010,31 (4) 45-49

瘦素影响强直性脊柱炎Th17相关细胞因子表达的研究

作  者：
李国青;刘延庆;张育;郭试瑜;久光正
单  位：
扬州大学;日本昭和大学
关键词：
强直性脊柱炎;瘦素;Th17细胞因子
摘  要：
取30例强直性脊柱炎(AS)患者和30例健康对照组外周血清和膝关节滑液,采用放射性免疫法和双抗体夹心酶免疫吸附法分析瘦素(leptin)、IL-17、TNF-α、IL-6含量,探讨leptin、Th17细胞因子与AS病情活动的相关性。结果表明:AS患者外周血和膝关节滑液中leptin、IL-17、TNF-α、IL-6含量比健康对照组明显升高(P<0.01)。AS外周血和关节滑液中leptin的表达水平与IL-17、IL-6呈显著相关(P<0.01),与TNF-α表达相关不显著。AS患者外周血清和关节滑液中leptin、IL-17、IL-6平均表达水平与AS患者的血沉、C-反应蛋白、Bath强直性脊柱炎活动指数呈显著相关(P<0.05),TNF-α的表达水平与AS病情活动指标相关不显著。说明leptin及Th17相关细胞因子在AS患者外周血和关节滑液中明显升高,可能直接参与了AS关节炎症过程。
译  名：
The effect of leptin on the Th17 correlated cytokine in ankylosing spondylitis
作  者：
LI Guo-qing1,LIU Yan-qing2,3,ZHANG Yu2,GUO Shi-yu3,HISAMITS Tadashi3(1.Coll of Clin Med,Yangzhou Univ,Yangzhou 225001,China;2.Coll of Med,Yangzhou Univ,Yangzhou 225001,China;3.Coll of Med,Showa Univ,Tokyo 1500000,Japan)
关键词：
ankylosing spondylitis;leptin;Th17 cytokine
摘  要：
To understand the association of leptin and Th17 correlated cytokines with AS patients diseases activity,leptin,IL-17,TNF-α,IL-6 in synovial fluid and peripheral sera collected from 30 patients with AS and 30 healthy control were detected using sandwich ELISA and RIA methods.Results showed that the concentrations of leptin,IL-17,TNF-α,IL-6 were significantly higher in the synovial fluid and peripheral sera in AS patients than those in healthy control(P <0.01).There were obvious correlation between leptin and IL-17,IL-6 expression in the synovial fluid and peripheral sera in AS patients(P< 0.01),and no correlation between leptin and TNF-α(P>0.05).There were obvious correlation between the mean expression of leptin,IL-17,IL-6 and ESR,CRP,BASDAI in AS patients(P< 0.01),and no correlation between TNF-α and the AS active index(P>0.05).Leptin and Th17 correlated cytokines significantly increased in the synovial fluid and sera of AS patients.Leptin may play an important role in the development of AS inflammation.

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