中国农业科学院农业信息研究所 中国农学会
Agricultural Information Institute of CAAS China Association of Agricultural Science Societies
En
Ch
中国农业科学院农业信息研究所 中国农学会 主办

AI检索

订阅

返回顶部
当前位置: 首页 > 文章 > 复方苦芩总多糖体外抗犬细小病毒作用机理研究 中国兽医杂志 2013,49 (7) 50-52
Position: Home > Articles > Study on the Mechanism of Resistance of Canine Parvovirus by the Total Polysaccharides of Compound Kuqin in Vitro Chinese Journal of Veterinary Medicine 2013,49 (7) 50-52

复方苦芩总多糖体外抗犬细小病毒作用机理研究

作  者：
朱买勋;邵秋红;刘娟;邱洪;徐杨峰
单  位：
西南大学荣昌校区动物医学系
关键词：
复方苦芩;多糖;犬细小病毒;抗病毒作用
摘  要：
为探讨复方苦芩总多糖体外抗犬细小病毒(CPV)感染F81细胞作用机制,以F81细胞为宿主细胞,复方苦芩和黄芪多糖作药物对照,从复方苦芩总多糖对CPV的直接灭活作用、阻滞作用、抑制吸附、穿入及其复制5个方面探讨复方苦芩总多糖抗CPV活性机理。结果显示,复方苦芩总多糖在CPV病毒复制过程中均有一定的抑制作用,其中直接灭活作用效果优于复方苦芩组,P<0.05,复制试验效果优于复方苦芩组,P<0.05,与阳性药物组差异不显著,P>0.05。从而表明复方苦芩总多糖体外抗CPV感染F81细胞效果明显,且主要通过直接灭活CPV和抑制其复制而发挥作用。
译  名：
Study on the Mechanism of Resistance of Canine Parvovirus by the Total Polysaccharides of Compound Kuqin in Vitro
作  者：
ZHU Mai-xun,SHAO Qiu-hong,LIU Juan,QIU Hong,XU Yang-feng(Department of Veterinary Medicine,Southwest University,Rongchang 402460,China)
关键词：
Compound Kuqin;Polysaccharides;Canine Parvovirus;Antiviral Activity
摘  要：
To investigate the antiviral mechanism of total polysaccharides of Kuqin compound on canine parvovirus infected F81 cells in vitro,we took the F81 as host cells,the compound Kuqin and Astragalus Polysaccharides as drug control,and explored the antiviral mechanism from five aspects: direct inactivation,blocking effect,adsorption assay,penetration assay and reproduction assay.The result indicated that the total polysaccharides of Kuqin compound could inhibit canine parvovirus replication and had better effect on direct inactivation assay and reproduction assay than Kuqin compound(P<0.05);compared with Astragalus Polysaccharides,it showed no obvious difference in reproduction assay(P>0.05).The study concluded that the total polysaccharide of Kuqin compound might resist canine parvovirus infected F81 cells in vitro,and its main antiviral mechanism might be to inactivate the CPV directly and inhibit the virus reproduction.

相似文章

导出引用
计量
文章访问数: 8
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊

友情链接Friendly link
农业信息研究所Agricultural information institute 农业智能知识服务平台Agricultural intelligent knowledge service platform 农业学术服务平台Agricultural Knowledge Service System 中国知网CNKI 维普网VIP 万方WANFANG DATA
联系我们Contact us

电话Tell：010-82109652-808

邮箱E-mail：agrijournal@caas.cn

服务Service
关于我们About us 意见建议Opinions and suggest
版权说明Copyright
单位：中国农业科学院农业信息研究所 中国农学会 © 2017中国农业科学院农业信息研究所 ICP备案号：京ICP备09089781号-46