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当前位置: 首页 > 文章 > 裸燕麦球蛋白源多肽对D-半乳糖致衰老小鼠抗氧化能力的影响 食品科学 2019 (23) 137-141
Position: Home > Articles > Effect of Peptide Derived from Naked Oat Globulin on Antioxidant Capacity in D-Galactose-Induced Aging Mice FOOD SCIENCE 2019 (23) 137-141

裸燕麦球蛋白源多肽对D-半乳糖致衰老小鼠抗氧化能力的影响

作  者：
付媛;张美莉;高韶辉;张宇
单  位：
内蒙古农业大学理学院;内蒙古农业大学食品科学与工程学院
关键词：
裸燕麦;球蛋白;多肽;抗氧化;衰老
摘  要：
研究裸燕麦球蛋白源多肽(peptide from naked oat globulin,PNOG)对D-半乳糖(D-galactose,D-gal)致衰老小鼠抗氧化能力的影响。采取连续6周颈背部皮下注射D-gal 120 mg/(kg m_b·d)建立小鼠亚急性衰老模型。将60只小鼠随机分为正常对照组,衰老模型组,PNOG低、中、高剂量治疗组(200、600、1 000 mg/(kg m_b·d))以及VC阳性对照组(100 mg/(kg m_b·d)),皮下注射同时灌胃给药,每天1次,连续6周。6周后测定小鼠体质量增量、肝及脑的脏器指数;血清中超氧化物歧化酶(superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)及过氧化氢酶(catalase,CAT)活力;肝、脑组织中GSH-Px、单胺氧化酶-B(monoamine oxidase B,MAO-B)活力及丙二醛(malondialdehyde,MDA)含量。结果表明:与正常对照组相比,衰老模型组小鼠体质量增加缓慢,脏器指数降低;血清中SOD、GSH-Px及CAT活力均显著降低(P<0.05);肝、脑组织中GSH-Px活力显著降低(P<0.05),MAO-B活性及MDA含量极显著升高(P<0.01)。灌胃中、高剂量PNOG后,可使衰老小鼠体质量显著提高,脏器指数增大;与衰老模型组相比,可显著提高血清中SOD、GSH-Px及CAT活力及肝、脑组织中GSH-Px活力,极显著降低MAO-B活力以及MDA含量(P<0.01)。表明PNOG能有效清除机体内产生的过量自由基,显著提高D-gal致衰老小鼠的抗氧化能力,具有量效关系。
译  名：
Effect of Peptide Derived from Naked Oat Globulin on Antioxidant Capacity in D-Galactose-Induced Aging Mice
作  者：
FU Yuan;ZHANG Meili;GAO Shaohui;ZHANG Yu;College of Sciences, Inner Mongolia Agricultural University;College of Food Science and Engineering, Inner Mongolia Agricultural University;
关键词：
naked oats;;globulin;;peptide;;antioxidant;;aging
摘  要：
To investigate the influence of peptide derived from naked oat globulin(PNOG) on antioxidant capacity in aging mice, a subacute aging mouse model was established by neck back subcutaneous injection of D-galactose(120 mg/(kg m_b·d)) once daily for 6 consecutive weeks. Healthy male mice were randomly divided into 6 groups: normal control group, aging model group, low-, medium-and high-dose PNOG groups(200, 600, 1 000 mg/(kg m_b·d)) and vitamin C(VC, positive control) group(100 mg/(kg m_b·d)). After 6 weeks, body mass, liver index and brain index were examined and the activities of superoxide dismutase(SOD), glutathione peroxidase(GSH-Px) and catalase(CAT) were measured in the serum of mice. The activities of GSH-Px and monoamine oxidase B(MAO-B) and malondialdehyde(MDA) content were measured in liver and brain tissues. The results showed that body mass in the aging model group increased more slowly, and liver and brain indexes decreased; the activities of SOD, GSH-Px and CAT in serum significantly declined(P < 0.05), and so did GSH-Px activity in liver and brain tissues(P < 0.05), but MAO-B activity and MDA content significantly increased as compared to the normal control group(P < 0.01). For the aging mice treated with PNOG at medium and high doses, body mass increased fast, and liver and brain indexes became greater. The activities of SOD and GSH-Px in serum as well as GSH-Px activity in liver and brain tissues significantly increased, and MAO-B activity and MDA content significantly declined(P < 0.01) as compared to aging model mice. These data indicated that PNOG could effectively remove free radicals, and significantly increase antioxidant capacity in D-gal-induced aging mice in a dose-dependent manner.

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