中国农业期刊集成服务平台

当前位置: 首页 > 文章 > An overview of aflatoxin B1 biotransformation and aflatoxin M1 secretion in lactating dairy cows 动物营养(英文) 2021,7 (1)

Position: Home > Articles > An overview of aflatoxin B1 biotransformation and aflatoxin M1 secretion in lactating dairy cows Animal Nutrition 2021,7 (1)

An overview of aflatoxin B1 biotransformation and aflatoxin M1 secretion in lactating dairy cows

作者：

Li Min;Johanna Fink-Gremmels;Dagang Li;Xiong Tong;Jing Tang;Xuemei Nan;Zhongtang Yu;Weidong Chen;Gang Wan

单位：

State Key Laboratory of Livestock and Poultry Breeding, Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science in South China, Guangdong Public Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, China; Corresponding author;State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China;Department of Animal Sciences, The Ohio State University, Columbus, USA;Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands

关键词：

Aflatoxin B1;Biotransformation;Aflatoxin M1;Dairy cow;Milk safet

摘要：

Milk is considered a perfect natural food for humans and animals. However, aflatoxin B1 (AFB1) contaminating the feeds fed to lactating dairy cows can introduce aflatoxin M1 (AFM1), the main toxic metabolite of aflatoxins into the milk, consequently posing a risk to human health. As a result of AFM1 monitoring in raw milk worldwide, it is evident that high AFM1 concentrations exist in raw milk in many countries. Thus, the incidence of AFM1 in milk from dairy cows should not be underestimated. To further optimize the intervention strategies, it is necessary to better understand the metabolism of AFB1 and its biotransformation into AFM1 and the specific secretion pathways in lactating dairy cows. The metabolism of AFB1 and its biotransformation into AFM1 in lactating dairy cows are drawn in this review. Furthermore, recent data provide evidence that in the mammary tissue of lactating dairy cows, aflatoxins significantly increase the activity of a protein, ATP-binding cassette super-family G member 2 (ABCG2), an efflux transporter known to facilitate the excretion of various xenobiotics and veterinary drugs into milk. Further research should focus on identifying and understanding the factors that affect the expression of ABCG2 in the mammary gland of cows.

相似文章

A new insight on alleviating the inhibitory effect of aflatoxin B1 on muscle development in grass carp (Ctenopharyngodon idella): The effect of 4-Methylesculetin in vivo and in vitro [Xiangning He, Jiajia Zhang, Weidan Jiang, Pei Wu, Yang Liu, Hongmei Ren, Xiaowan Jin, Hequn Shi, Xiaoqiu Zhou, Lin Fen] 动物营养（英文） 2024,19
A Saccharomyces cerevisiae RC016-based feed additive reduces liver toxicity, residual aflatoxin B1 levels and positively influences intestinal morphology in broiler chickens fed chronic aflatoxin B1-contaminated diets [Valeria Poloni, Alejandra Paola Magnoli, Analía Fochesato, Andrea Cristofolini, Matías Daniel Caverzán, Cecilia Inés Merkis, Mariana Montenegro, Lilia Reneé Cavaglier] 动物营养（英文） 2020,6 (1)
Effects of aflatoxin B1 on subacute exposure of hybrid groupers (Epinephelus fuscoguttatus♀ × Epinephelus lanceolatus♂): Growth, liver histology, and integrated liver transcriptome and metabolome analysis [Hao Liu, Shuqing Liang, Weibin Huang, Yuanzhi Yang, Menglong Zhou, Baiquan Lü, Biao Li, Wenshan Cai, Hengyang Song, Beiping Tan, Xiaohui Don] 动物营养(英文) 2024,19
Aflatoxin B1 decreased flesh flavor and inhibited muscle development in grass carp (Ctenopharyngodon idella) [Xiang-Ning He, Zhen-Zhen Zeng, Wei‐Dan Jiang, Pei Wu, Yang Liu, Sheng‐Yao Kuang, Ling Tang, Shuwei Li, Lin Feng, Xiao‐Qiu Zho] 动物营养（英文） 2024,18
Occurrence of Aflatoxin B(1), deoxynivalenol and zearalenone in feeds in China during 2018–2020 [Ling Zhao, Lei Zhang, Zijian Xu, Xingda Liu, Liyuan Chen, Jie-Fan Dai, Niel A. Karrow, Luo Su] 畜牧与生物技术杂志(英文版) 2021,12 (1)

导出引用

计量

文章访问数: 9

HTML全文浏览量: 0

PDF下载量: 0

An overview of aflatoxin B1 biotransformation and aflatoxin M1 secretion in lactating dairy cows

相似文章

所属期刊

动物营养(英文)

推荐期刊

动物营养(英文)

畜牧与生物技术杂志(英文版)