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当前位置: 首页 > 文章 > 海水浸泡对大鼠血液指标和主要脏器组织结构的影响 动物医学进展 2018 (5) 64-68
Position: Home > Articles > Effects of Cold Seawater Immersion on Hematology and Histopathology of Some Important Organs in Rats Progress in Veterinary Medicine 2018 (5) 64-68

海水浸泡对大鼠血液指标和主要脏器组织结构的影响

作  者：
陈丽娜;奂剑波;史成和;袁丹凤;代维;周继红;韩志海
关键词：
大鼠;海水浸泡;血液学;病理;肝功能;肾功能
摘  要：
为了探讨低温海水浸泡对大鼠血液学和心、肝、肾、肺组织病理学的影响,将20只健康雄性SD大鼠(试验前10天腹腔植入温度记录器),随机分为正常组和低温组。正常组室温放置5h,低温组15℃±0.5℃人工海水中浸泡5h。比较两组大鼠血常规、凝血、肝肾功能的差异,观察心、肝、肾、肺组织病理学的改变。海水浸泡2h后,大鼠腹腔温度与水温接近,并维持到5h。低温组大鼠的红细胞、血红蛋白、红细胞压积及中性粒百分比均增加(P<0.01),白细胞和血小板计数降低(P<0.01);凝血酶原时间、活化部分凝血活酶时间及国际化标准比率均增加(P<0.05);AST、ALT、尿素及肌酐均明显增加(P<0.05);心脏和肾脏组织病理形态学改变较小,肝组织病理学表现散在性出血,肺组织表现显著的淤血和水肿,并伴有出血和炎性细胞浸润。低温海水浸泡导致大鼠血常规、凝血、肝肾功能明显异常,肺组织有显著的病理学损伤发生,肝脏次之,心脏和肾脏病理损伤轻微。
译  名：
Effects of Cold Seawater Immersion on Hematology and Histopathology of Some Important Organs in Rats
作  者：
CHEN Li-na;HUAN Jian-bo;SHI Cheng-he;YUAN Dan-feng;DAI Wei;ZHOU Ji-hong;HAN Zhi-hai;Navy Clinical College of Anhui Medical University,Department of Respiratory and Critical Care Medicine,Navy General Hospital;Navy General Hospital Naval War Treatment Research Center;Fourth Department,Research Institute of Surgery,Daping Hospital,Third Military Medical University;
单  位：
CHEN Li-na%HUAN Jian-bo%SHI Cheng-he%YUAN Dan-feng%DAI Wei%ZHOU Ji-hong%HAN Zhi-hai%Navy Clinical College of Anhui Medical University,Department of Respiratory and Critical Care Medicine,Navy General Hospital%Navy General Hospital Naval War Treatment Research Center%Fourth Department,Research Institute of Surgery,Daping Hospital,Third Military Medical University
关键词：
rat;;seawater immersion;;hematology;;histopathology;;liver function;;renal function
摘  要：
To investigate the effects of cold seawater immersion on hematology and histopathology of heart,liver,kidney and lung in rats,20 healthy SD male rats(10 days before the experiment)were randomly divided into normal group and cold seawater immersion group.The rats in normal group were set in room temperature for 5 hand cold seawater immersion group were immersed in 15℃±0.5℃artificial seawater for5 h.The changes of blood routine,coagulation,liver and kidney function and the histopathology of heart,liver,kidney and lung were observed.After immersing for 2 h,the rat abdominal temperature was close to water temperature and maintained to 5 h.Compared with the normal group,the percentages of red blood cells,hemoglobin,hematocrit and neutrophils of rats in cold seawater immersion group increased(P <0.01),leukocyte and platelet counts decreased(P<0.01).The levels of prothrombin time,activated partial thromboplastin time and international standard ratio were increased(P<0.05);AST,ALT,urea and creatinine were significantly increased(P<0.05).There was no significant change in histopathology of heart and kidney.but the histopathology of lung and liver were abnormal obviously.Blood routine,coagulation,liver and kidney function were significantly changed by cold seawater immersion and the pathological lesion of lung was prominent,followed by the liver,however the pathological damage of heart and kidney were not obvious.

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