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当前位置: 首页 > 文章 > 灌胃不同奶样对BALB/c小鼠致敏性的影响 中国畜牧兽医 2017 (7) 2191-2196
Position: Home > Articles > Effects of Different Milk Samples on Sensitization in BALB/c Mice China Animal Husbandry & Veterinary Medicine 2017 (7) 2191-2196

灌胃不同奶样对BALB/c小鼠致敏性的影响

作  者：
白娜;明亮;高婉婷;郭富城;乔向宇;朝格苏力德;郭雁;伊日贵;刘东辉;吉日木图
单  位：
内蒙古农业大学乳品生物技术与工程教育部重点实验室;内蒙古骆驼研究院
关键词：
BALB/c小鼠;驼奶;牛奶;过敏;β-乳球蛋白
摘  要：
本试验研究了驼奶、牛奶和人奶对BALB/c小鼠的致敏性强弱,将60只小鼠随机分为5组,每组12只,分别为β-乳球蛋白(β-lg)组(阳性对照组)、牛奶组、驼奶组、人奶组和空白组(阴性对照组),每组分别灌胃1mg/g体重的样品和0.3μg/g体重的霍乱弧菌毒素(CT),空白组灌胃PBS和CT,每周1次。灌胃6周后,通过观察过敏症状,检测血清特异性免疫球蛋白E(IgE)和IgG1、血浆组胺水平及血管通透性等指标,比较几种奶源的致敏性强弱。结果显示,驼奶组、人奶组和空白组小鼠体重正常增长,而β-lg组和牛奶组的体重增长有减慢的趋势。与空白组相比,β-lg组和牛奶组的血清特异性IgE和IgG1水平极显著升高(P<0.01),组胺水平极显著升高(P<0.01),血管通透性增加,过敏症状明显;而驼奶组小鼠血清IgE和IgG1水平极显著低于牛奶组(P<0.01),但与人奶组相比无显著差异(P>0.05),过敏症状轻微,表明驼奶的致敏性明显低于牛奶,且与人奶相似。
译  名：
Effects of Different Milk Samples on Sensitization in BALB/c Mice
作  者：
BAI Na;MING Liang;GAO Wan-ting;GUO Fu-cheng;QIAO Xiang-yu;CHAOGE Sulide;GUO Yan;YI Ri-gui;LIU Dong-hui;JI Rimutu;Key Laboratory of Dairy Biotechnology and Bioengineering,Ministry of Education,Inner Mongolia Agricultural University;Camel Research Institute of Inner Mongolia;
关键词：
BALB/c mice;;camel milk;;cow milk;;allergy;;β-lg
摘  要：
In order to study the allergenicity of camel milk,cow milk and human milk,sixty BALB/c mice were randomly divided intoβ-lactoglobulin(β-lg)group(positive control group),cow milk group,camel milk group,human milk group and blank group(negative control group).Each group of mice received 1 mg/g BW samples and 0.3μg/g cholera toxin(CT)per week,while mice in control group were received PBS and CT.After six weeks of intragastric administration,some allergic symptoms,the serum specific immunoglobulin E(IgE)and immunoglobulin G1(IgG1)levels,plasma histamine levels and vascular permeability were detected.The results showed that the body weight of mice in camel milk,human milk and blank groups were normally increased,while that inβ-lg and cow milk groups tended to slow down.The serum-specific IgE,IgG1 levels and histamine level inβ-lg and cow milk groups were extremely significantly higher than blank group(P<0.01),the vascular permeability was increased,and the allergy symptoms were obvious.While the specific IgE and IgG1 levels of camel milk group were extremely signifi-cantly lower than cow milk group(P<0.01),but there were no significant difference with human milk group(P>0.05),and the allergy symptoms were mild.This study showed that the sensitization of camel milk was lower than cow milk,and similar to human milk.

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