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当前位置: 首页 > 文章 > 不同生理阶段及性别SPF级BALB/c小鼠和C57BL/6小鼠血液生理生化指标测定与比较 广东农业科学 2019 (12) 102-109
Position: Home > Articles > Determination and Comparison of Blood Physiological and Biochemical Indexes Between SPF BALB/c Mice and C57BL/6 Mice in Different Physiological Stages and Genders Guangdong Agricultural Sciences 2019 (12) 102-109

不同生理阶段及性别SPF级BALB/c小鼠和C57BL/6小鼠血液生理生化指标测定与比较

作  者：
黎桂玲;刘科;黎雄才;邝少松;王刚
单  位：
广东省医学实验动物中心
关键词：
BALB/c小鼠;C57BL/6小鼠;血常规;血生化;性成熟;体成熟
摘  要：
【目的】测定6周龄与9周龄BALB/c小鼠和C57BL/6小鼠的血常规、血生化值并进行比较分析。【方法】用全自动血细胞分析仪、全自动生化分析仪分别测定血常规、血生化值。【结果】(1)相同生理阶段的BALB/c异性小鼠血常规值中NE%、LY%差异极显著,不同生理阶段的同性小鼠LY%、HGB等8项指标差异显著;相同生理阶段的C57BL/6异性小鼠血常规值中RBC、WBC等7项指标差异显著,不同生理阶段的同性小鼠WBC、NE等6项指标差异显著。(2)6周龄BALB/c异性小鼠所有检测血生化指标差异不显著,随着生理阶段的变化,AST、ALP等8项指标差异极显著,不同生理阶段的同性小鼠ALP、GLU等7项指标差异显著;相同生理阶段的C57BL/6异性小鼠血生化指标差异不显著,不同生理阶段的同性小鼠ALP、GLU等7项指标差异显著。(3)随着生理阶段的变化,BALB/c小鼠与C57BL/6小鼠血液生理生化部分指标差异性增大。【结论】生理阶段、性别均对小鼠血液生理生化指标有显著性影响。
译  名：
Determination and Comparison of Blood Physiological and Biochemical Indexes Between SPF BALB/c Mice and C57BL/6 Mice in Different Physiological Stages and Genders
作  者：
LI Guiling;LIU Ke;LI Xiongcai;KUANG Shaosong;WANG Gang;Guangdong Medical Laboratory Animal Center;
关键词：
BALB/c mice;;C57BL/6 mice;;blood routine;;blood biochemical;;sexual maturity;;body?maturity
摘  要：
【Objective】The study was conducted to measure and compare the blood routine and blood biochemical values of 6 weeks old and 9 weeks old BALB/c mice and C57BL/6 mice.【Methods】Blood routine and biochemical values were determined by automatic blood cell analyzer and automatic biochemical analyzer.【Results】(1) There were extremely significant differences in 2 blood physiological indicators(NE% and LY%) of heterosexual BALB/c mice at the same physiological stage,and there were significant differences in 8 indicators (LY%,HGB and etc.) in homosexual mice at different physiological stages.There were significant differences in 7 blood physiological indicators (RBC and WBC and etc.) of heterosexual C57BL/6 mice at the same physiological stage,and there were significant differences in 6 indicators (WBC and NE and etc.) of homosexual mice at different physiological stages.(2) There was no significant difference in the biochemical indexes between the heterosexual 6 weeks old mice,with the changes of physiological stages,and there were extremely significant differences in 8 blood biochemical indicators (AST,ALP and etc.).There was no significant difference in the biochemical indexes of heterosexual C57BL/6 mice at the same physiological stage,but there were significant differences in 7 blood biochemical indicators (ALP,GLU and etc.).(3) With the changes of physiological stages,there was an increase in the difference in part of blood physiological and biochemical indicators of BALB/c mice and C57BL/6 mice.【Conclusions】The physiological and biochemical indexes of mice blood are significantly affected by the physiological stage and gender of mice.

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