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Position: Home > Articles > Synthesis of Imidacloprid Using Nitroguanidine Agrochemicals 2014,53 (1) 17-19+22

硝基胍法制备吡虫啉工艺

作  者:
郑亚清;丁克鸿;冀超;张寅;胡俊;孙伟
单  位:
江苏扬农化工集团有限公司
关键词:
2-氯-5-氯甲基吡啶;硝基胍;吡虫啉;合成
摘  要:
[目的]吡虫啉是重要的烟碱类杀虫剂,对其合成工艺进行优化。[方法]以2-氯-5-氯甲基吡啶为原料,合成出中间体N-(6-氯-3-吡啶甲基)乙撑二胺,采用硝基胍法对吡虫啉的合成工艺进行研究。考察体系pH值、温度、时间、原料配比等因素对反应的影响。[结果]在优化的反应条件下,合成最终产品吡虫啉收率达到78.0%(以硝基胍计),纯度达到98.98%。[结论]该工艺收率高、产品纯度高,适宜工业化生产。
译  名:
Synthesis of Imidacloprid Using Nitroguanidine
作  者:
ZHENG Ya-qing;DING Ke-hong;JI Chao;ZHANG Yin;HU Jun;SUN Wei;Jiangsu Yangnong Chemical Group Co.,Ltd.;
关键词:
2-chloro-5-chloromethylpyridine;;nitroguanidine;;imidacloprid;;synthesis
摘  要:
[Aims]Imidacloprid is an important lnsecticide, the study aims to optimize the synthetic process. [Methods] The intermediate N-(2-chloro-5-pyridylmethyl)-ethylenediamine was prepared using 2-chloro-5-chloromethylpyridine as the raw material. And then the synthesis of imidacloprid was studied by method of nitroguanidine. Meanwhile the effects of pH value, temperature, time and raw material ratio on the reaction were studied as well. [Results][Results] Under the optimal condition, the total yield was 78.0% based on nitroguanidine and the purity was 98.98%. [Conclusions][Conclusions] The synthetic process has some advantages of high yield, high purity, which is suitable for industrial production.

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