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当前位置: 首页 > 文章 > 大蒜多糖对四氯化碳致小鼠肝炎血清及组织转氨酶影响 甘肃农业大学学报 2008,43 (4) 40-42
Position: Home > Articles > Effect of GPA on GOT and GPT in serum and liver of mice injured by CCl_4 Journal of Gansu Agricultural University 2008,43 (4) 40-42

大蒜多糖对四氯化碳致小鼠肝炎血清及组织转氨酶影响

作  者：
姜中毅;程富胜;苏鹏
单  位：
甘肃农业大学动物医学院;中国农业科学院兰州畜牧与兽药研究所新兽药工程实验室
关键词：
大蒜多糖;肝炎;谷丙转氨酶;谷草转氨酶;四氯化碳
摘  要：
通过大蒜多糖(GPA)对四氯化碳(CCl4)致肝炎模型小鼠血清和肝组织中谷丙转氨酶(GPT)和谷草转氨酶(GOT)的影响,以探讨大蒜多糖对小鼠肝脏组织的保护作用.采用CCl4灌胃建立小鼠化学性肝炎模型,用大蒜多糖对肝炎模型小鼠进行治疗,7 d后眼眶采血,取肝组织,赖氏法测定血清和肝组织匀浆中GPT和GOT的活力.结果表明:大蒜多糖能明显降低肝炎模型小鼠血清和肝组织中的GPT和GOT活力,说明大蒜多糖对急性化学性肝炎具有抗炎保肝作用.
译  名：
Effect of GPA on GOT and GPT in serum and liver of mice injured by CCl_4
作  者：
JIANG Zhong-yi1,2,CHENG Fu-sheng2,SU Peng2(1.College of Veterinary Medicine,Gansu Agricultural University,Lanzhou 730070,China;2.Laboratory of New Animal Medicine Project,Lanzhou Institute of Animal & Veterinary Pharmaceutics Science,Lanzhou 730050,China)
关键词：
garlic polysaccharide;hepatitis;glutamic-pyuric-transaminase;glutamic-oxalacetic transaminase;CCl4
摘  要：
The glutamic-oxalacetic transaminase(GOT) and glutamic-pyuric transaminase(GPT) were studied in serum and liver of mice injured by CCl4,to investigate the protection of garlic polysaccharide(GPA) against the hepatitis.Mouse chemical hepatitis model was established by gavage CCl4,and the mice were treated by different concentrations of GPA,after seven days,all mice were killed,the tissue was taken out from the bodies and the serum out from eyes,the activities of the GOT and GPT in serum and liver were tested by Reite's method.The results showed that the garlic polysaccharide could decline the activities of GOT and GPT in serum and liver tissue,and had effects of prevention and treatment on acute chemical hepatitis.

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