摘 要：
试验旨在探讨白凤菜的降血糖作用,为临床推广使用提供科学依据。本研究采用水萃取法制备白凤菜干膏制剂,将试验动物分为不同剂量药物组,连续灌胃5d,并以二甲双胍为阳性对照药物,在机体糖负荷情况下以尾静脉血糖值、糖耐量曲线下面积为检测指标,研究白凤菜对正常小鼠糖耐量的影响。试验在第5次灌服生药用量(1g/d)后的30~120min血糖值迅速下降并在120 min(3.16 mmol/L)低于0基准血糖值(4.00 mmol/L),1~2g/d生药用量的糖耐量曲线下面积小于二甲双胍组的糖耐量曲线下面积。得出1~2g/d的白凤菜囗服液连续服用5d后具有阻止(抑制)胃肠在机体糖负荷情况下对葡萄糖的吸收的作用,其作用优于盐酸二甲双胍。
译 名：
Study on the Effect of Gynura formosana Kitam.on Glucose Tolerance
作 者：
GU Yuan-yin;DING Shu-mei;SUN Cui-cui;LIU Qun;School of Life Science and Technology,Southwest University for Nationalities;
关键词：
Gynura formosana Kitam;;blood glucose levels;;SBG
摘 要：
The study was aimed to explore the hypoglycemic effect of the Gynura formosana Kitam.,which would provide a scientific basis for clinical expansion.This research adopted the water extraction of Gynura formosana Kitam.dry paste.Some experimental animals were divided into different dose groups,and intragastrically administrated for 5days,and used metformin as the positive control drug in the body load cases by tail vein blood glucose and glucose tolerance area under the curve as testing indexes,so that we could study the effect of Gynuraformosana Kitam.on the normal glucose tolerance for mice.Test in 30 to 120min later,when the mice were drench in the fifth crude drug dosage(1g/d),the blood glucose dropped rapidly,and at the moment of the 120 th min,(tendency for 3.16mmol/L)the blood glucose level was less than the 0benchmark of blood glucose(4.00 mmol/L).1to 2g/d glucose tolerance area under curve of crude drug dosage was less than the metformin group of glucose tolerance area under the curve.We could work out that 1to 2g/d for Gynura formosana Kitam.oral liquid,insisted on taking them for 5days,would restrained(suppress)gastrointestinal sugar in the body to absorb glucose load situations,and its effect is better than that of metformin hydrochloride.
