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当前位置: 首页 > 文章 > 鲁中肉羊BMP4基因g.63454744 T>G位点多态性与产羔数的关联分析 中国草食动物科学 2019 (3) 11-13+17
Position: Home > Articles > Polymorphism of g.63454744 T>G Locus of Luzhong Mutton Sheep BMP4 Gene and Its Association with Litter Size China Herbivore Science 2019 (3) 11-13+17

鲁中肉羊BMP4基因g.63454744 T>G位点多态性与产羔数的关联分析

作  者：
文禹粱;潘林香;王金文;马琳;赵生国;储明星
单  位：
山东省农业科学院畜牧兽医研究所;中国农业科学院北京畜牧兽医研究所农业部动物遗传育种与繁殖重点实验室;甘肃农业大学动物科学技术学院;莱芜市嬴泰有机农业科技发展有限公司
关键词：
鲁中肉羊;BMP4基因;SNP分型;产羔数
摘  要：
为了探索骨形态发生蛋白4(Bone morphogenetic protein 4,BMP4)基因g.63454744T>G位点多态性与绵羊产羔数之间的关系,对前期重测序中筛选得到的BMP4基因编码区错义突变单核苷酸多态性位点(Single nucleotide polymorphism site, SNP)g.63454744T>G在384只鲁中肉羊中利用Sequenom MassARRAY~? SNP技术进行分型,再将分型结果与鲁中肉羊产羔数进行关联分析。结果表明:BMP4基因g.63454744T>G位点在鲁中肉羊中存在TT、GT和GG三种基因型;该位点在鲁中肉羊中表现为中度多态(0.250.05)。说明BMP4基因g.63454744T>G位点不适合用于鲁中肉羊产羔数选育。
译  名：
Polymorphism of g.63454744 T>G Locus of Luzhong Mutton Sheep BMP4 Gene and Its Association with Litter Size
作  者：
Wen Yuliang;Pan Linxiang;Wang Jinwen;Ma Lin;Zhao Shengguo;Chu Mingxing;Key Laboratory of Animal Genetics,Breeding and Reproduction of Ministry of Agriculture,Institute of Animal Science,Chinese Academy of Agricultural Sciences;College of Animal Science and Technology,Gansu Agricultural University;Laiwu Yingtai Organic Agriculture Science and TechnologyDevelopment Co.Ltd;Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences;
关键词：
Luzhong Mutton sheep;;BMP4 gene;;SNP genotyping;;litter size
摘  要：
In order to explore the relationship between the polymorphism of the g.63454744 T>G locus in bone morphogenetic protein 4(BMP4)gene and the litter size in sheep. In previous work,the locus of g.63454744 T>G in BMP4 gene was found by sheep genome resequencing. Then the genotypes of g.63454744 T>G were detected by Sequenom Mass ARRAY~? SNP technique in384 Luzhong Mutton sheep and the association between the mutation and litter size in Luzhong Mutton sheep was analyzed. The result of genotyping showed that three genotypes(TT,GT,GG)were found at g.63454744 T>G in BMP4 gene. Population genetic analysis showed that the g.63454744 T>G locus had a moderate polymorphism(0.25G locus was not under Hardy-Weinberg equilibrium(P<0.05) in this Luzhong Mutton sheep population. Association analysis indicated that the polymorphisms of g.63454744 T>G had no significantly associated with each parity litter size in Luzhong Mutton sheep(P >0.05).Therefore,the polymorphism of the locus of g.63454744 T>G in BMP4 gene had no significant effect on litter size of Luzhong Mutton sheep.

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