中国农业科学院农业信息研究所 中国农学会
Agricultural Information Institute of CAAS China Association of Agricultural Science Societies
En
Ch
中国农业科学院农业信息研究所 中国农学会 主办

AI检索

订阅

返回顶部
当前位置: 首页 > 文章 > 加丽素红急性毒性及其对大鼠血液生理生化指标的影响 中国兽医杂志 2013,49 (7) 18-20
Position: Home > Articles > Studies on the Acute Toxicity of Carophyll Red and its effect on Physiological and Biochemical Indexes of Blood of Rats Chinese Journal of Veterinary Medicine 2013,49 (7) 18-20

加丽素红急性毒性及其对大鼠血液生理生化指标的影响

作  者：
杨兰兰;徐昆龙;高明艳;刘文文;施瀚超;朱姿英
单  位：
昆明市动物疫病预防控制中心;云南农业大学动物科学技术学院;中国人民解放军成都军区昆明总医院内分泌科
关键词：
加丽素红;急性毒性;生理生化指标;影响
摘  要：
本文用加丽素红悬浊液分别对ICR小鼠和SD大鼠进行灌胃试验,研究加丽素红对小鼠的急性毒性作用和对大鼠生理生化指标的影响。研究结果表明,加丽素红的LD50为81.43g/kg体重。根据WHO 1977年颁布的毒性分级标准,加丽素红的LD50大于5g/kg体重,因此可判断为实际无毒范围。灌胃后各时间段血液生理指标(白细胞数目、淋巴细胞数目、单核细胞数目等)与灌胃前相比均无显著差异(P>0.05);灌胃后试验组大鼠各时间段胆碱酯酶(CHE)与灌胃前相比,第12小时显著性升高(P<0.05);谷草转氨酶(AST)与灌胃前相比,第24、36、48小时显著性升高(P<0.05);谷丙转氨酶(ALT)与灌胃前相比,第24小时显著性升高(P<0.05);各时间段ALP(碱性磷酸酶)与灌胃前相比,无显著差异(P>0.05)。本试验表明加丽素红虽然毒性小,但一次性大剂量灌胃后的12～24h内能对肝脏功能指标造成一定的影响,即胆碱酯酶、谷草转氨酶和谷丙转氨酶著性升高。
译  名：
Studies on the Acute Toxicity of Carophyll Red and its effect on Physiological and Biochemical Indexes of Blood of Rats
作  者：
YANG Lan-lan1,XU Kun-long1,GAO Ming-yan1,LIU Wen-wen1,SHI Han-chao1,ZHU Zi-ying2(1.Animal disease control and prevention centres of Kunming,Kunming 650223,China; 2.College of Animal Science and Technology,Yunnan Agricultural University,Kunming 650201,China; 3.Endocrinology Department of Kunming Ggeneral Hospital,Chengdu Military Region,Kunming 650032,China)
关键词：
Carophyll red;Acute Toxicity;Blood Routine and Biochemical Indexes;Effects
摘  要：
This study investigates the acute toxicity of carophyll red and its effect on physiological and biochemical indexes of blood of ICR and SD rats in the form of solution by gavages has been used.The result showed that the LD50 of carophyll red was 81.43 g/kg.According to "Exogenous Chemicals of Toxicity Classification Standard",the carophyll red was actually non-toxic.Physiological and biochemical indexes of blood(including of eighteen indexes such as WBC、Lymph、Mon and so on)at any moment had no significant difference(P>0.05),as compared with the group before gavage.The cholinesterase(CHE) of the experimental group at 12 hours was significantly higher than that of the group before gavage(P<0.05).Compared with the group before gavage,the millet straw transaminase(AST) of the experimental group at 24,36,48 hours was significantly higher(P<0.05).The cereal third transaminase(ALT)of the experimental group at 24 hour was significantly higher than that of the group before gavage(P<0.05).Compared with the group before gavage,the ALP had no significant difference(P>0.05).Therefore,the conclusion is that the toxicity of carophyll red was minimal in rats,however,certain effects will be produced by the carophyll red at high dosage.

相似文章

导出引用
计量
文章访问数: 8
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊

友情链接Friendly link
农业信息研究所Agricultural information institute 农业智能知识服务平台Agricultural intelligent knowledge service platform 农业学术服务平台Agricultural Knowledge Service System 中国知网CNKI 维普网VIP 万方WANFANG DATA
联系我们Contact us

电话Tell：010-82109652-808

邮箱E-mail：agrijournal@caas.cn

服务Service
关于我们About us 意见建议Opinions and suggest
版权说明Copyright
单位：中国农业科学院农业信息研究所 中国农学会 © 2017中国农业科学院农业信息研究所 ICP备案号：京ICP备09089781号-46