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当前位置: 首页 > 文章 > 羧甲基茯苓多糖对肠癌小鼠生命延长及对环磷酰胺的减毒作用 食品科学 2016,37 (21) 229-233
Position: Home > Articles > Effect of Carboxymethyl Pachymaran on Life Extension and Attenuation of Cyclophosphamide-Induced Toxicity in CT26 Tumor-Bearing Mice FOOD SCIENCE 2016,37 (21) 229-233

羧甲基茯苓多糖对肠癌小鼠生命延长及对环磷酰胺的减毒作用

作  者：
王灿红;霍小位;何晓山;刘冬羽;李立勇;曹丽
单  位：
中国医学科学院药用植物研究所;云南中医学院中药学院
关键词：
羧甲基茯苓多糖;结肠癌;免疫调节;环磷酰胺;减毒作用;生命延长
摘  要：
目的:研究羧甲基茯苓多糖(carboxymethyl pachymaran,CMP)对结肠癌(CT26)小鼠的生命延长及对环磷酰胺(cyclophosphamide,CTX)的减毒作用。方法:建立小鼠CT26皮下移植瘤模型,减毒增效实验分为:模型组、CTX组、CMP+CTX组;延长生命实验分为:模型组、CMP低、中、高剂量组。检测外周血白细胞(white blood cell,WBC)数、骨髓有核细胞(bone marrow nucleated cell,BMNC)数、肿瘤抑制率、脏器指数以及肿瘤组织中信号调节蛋白-α(signal?regulatory?protein-α,SIRP-α)和巨噬细胞表面标志物(F4/80)的表达,统计生命延长率和中位生存期。结果:CMP抑制CTX化疗所致的脾脏和胸腺指数的降低及WBC和BMNC数量的减少,拮抗肝脏指数升高,降低SIRP-α和F4/80的表达,并延长小鼠带瘤生存时间。结论:CMP明显减轻CTX的毒副作用,且具有调节肿瘤免疫相关蛋白表达和延长CT26小鼠带瘤生存时间的作用。
译  名：
Effect of Carboxymethyl Pachymaran on Life Extension and Attenuation of Cyclophosphamide-Induced Toxicity in CT26 Tumor-Bearing Mice
作  者：
WANG Canhong;HUO Xiaowei;HE Xiaoshan;LIU Dongyu;LI Liyong;CAO Li;Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences;Department of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine;
关键词：
carboxymethyl pachymaran(CMP);;colon cancer;;immune regulation;;cyclophosphamide(CTX);;reducing toxicity;;life extending
摘  要：
Objective:To investigate the effect of carboxymethyi pachymaran(CMP) on life extension of colon tumor 26(CT26)-bearing mice and mitigating the side effects caused by chemotherapy with cyclophosphamide(CTX).Methods:CT26 tumor-bearing mouse models were established by subcutaneous transplantation into mice,and they were randomly divided into model,CTX and CTX + CMP groups for toxicity test.The model,and low-,medium- and high-dose CMP,groups were used for life extension test.Peripheral white blood cells(WBC),bone marrow nucleated cells(BMNC),percentage tumor inhibition,and visceral organ indexes were tested by biochemical assays.The expression of signal regulating protein alpha(SIRP-α) and macrophage surface marker(F4/80) in tumor tissues were detected through immunohistochemistry.Meanwhile,life extension rate and median survival period were observed.Results:CMP could increase the lower spleen index and thymus index,and the decreased levels of WBC and BMNC induced by CTX,antagonize the increase in liver index,and reduce the expression of SIRP-α and F4/80 in tumor tissues.In addition,CMP also could extend the survival time of CT26 tumor-bearing mice.Conclusion:CMP can obviously reduce the side effects of CTX,regulate the expression of tumor immune-related proteins,and prolong the survival time of CT26 tumor-bearing mice.

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