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Position: Home > Articles > Progresses on the Gene Difference between BCG and Wild Strains of Mycobacterium Tuberculosis Jilin Animal Husbandry and Veterinary Medicine 2011,32 (4) 11-14

卡介苗与结核菌野毒株的基因差异的研究进展

作  者:
刘东旭;时坤;李健明;杜锐
单  位:
吉林农业大学中药材学院
关键词:
卡介苗;结核分枝杆菌;牛型结核分枝杆菌;基因差异;RD1RD2RD3
摘  要:
人类结核已经存在数千年之久,无一个国家能幸免于难,尤其是第三国家。人们在感染结核病的同时也能感染艾滋病,这给人类的健康带来了巨大的挑战。现阶段,预防结核病的唯一方法就是接种BCG-减毒牛型结核分枝杆菌活疫苗。该疫苗是在1908年,由Leon Calmette和Camile Guerin将一株牛型结核分枝杆菌强毒株经历13年230次传代培养,使其毒力发生变异,成为对人无致病性,而保持了良好的免疫原性的菌株。本文主要是探讨结核分枝杆菌,牛型结核分枝杆菌和卡介苗之间的基因的差异。为卡介苗的改良和结核病的检测提供有益借鉴。
译  名:
Progresses on the Gene Difference between BCG and Wild Strains of Mycobacterium Tuberculosis
作  者:
LIU Dong-xu , SHI Kun , LI Jian-ming , DU Rui (College of Chinese Medicinal Materials , Jilin Agricultural University , ChangchunJilin 130118)
关键词:
BCG;Mycobacterium tuberculosis; Mycobacterium bovis ;gene difference; RD1 RD2 RD3
摘  要:
Tuberculosis has existed for thousands years and each country has infected with TB , especially in third countries, people infected with both TB and HIV. It bring a great challenge for human's health safety . Now , the best way to prevent tuberculosis is BCG-Mycobacterium bovis attenuated strain . In 1980, by Leon Calmette and Camile Guerin , virulent strain of Mycobacterium tuberculosis through 13 years of 230 subculture obtain BCG. BCG virulence had changed , non-pathogenic for hunman and maintain good immunogenicity . This article is study the gene difference between Mycobacterium tuberculosis, Mycobacterium bovis and BCG . for modified of BCG and detection of TB provide help.

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