中国农业科学院农业信息研究所 中国农学会
Agricultural Information Institute of CAAS China Association of Agricultural Science Societies
En
Ch
中国农业科学院农业信息研究所 中国农学会 主办

AI检索

订阅

返回顶部
当前位置: 首页 > 文章 > 内分泌干扰素氰戊菊酯对成年雄性小鼠繁殖生理的影响 上海农业学报 2010,26 (2) 11-14
Position: Home > Articles > The effect of endocrine disruptor fenvalerate on the reproductive physiology of adult male mice Acta Agriculturae Shanghai 2010,26 (2) 11-14

内分泌干扰素氰戊菊酯对成年雄性小鼠繁殖生理的影响

作  者：
徐克斯;蒋辉;杭怡琼;薛惠琴;夏东
单  位：
上海市农业科学院畜牧兽医研究所
关键词：
氰戊菊酯;雄性小鼠;繁殖生理
摘  要：
为了探讨氰戊菊酯对雄性小鼠繁殖性能及生理机制的影响,将成年雄性昆明小鼠用10 mg/kg BW氰戊菊酯连续灌胃40 d,分析其对小鼠精子质量、睾丸组织结构和血清睾酮、雌二醇含量的影响。结果表明:试验组小鼠精子密度与活率和对照组差异不显著,但试验组精子畸形率显著增加。透射电镜结果表明:试验组小鼠睾丸精母细胞线粒体出现肿胀和空泡化,支持细胞线粒体有肿胀现象,并且溶酶体增多,内质网明显扩张。试验组小鼠血清睾酮水平极显著高于对照组,雌二醇水平显著高于对照组。研究结果表明:用10 mg/kg BW氰戊菊酯长期灌胃雄性成年小鼠,可扰乱小鼠雄激素和雌激素的分泌,并影响小鼠的精子发生,导致小鼠繁殖性能下降。
译  名：
The effect of endocrine disruptor fenvalerate on the reproductive physiology of adult male mice
作  者：
XU Ke-si,JIANG Hui,HANG Yi-qiong,XUE Hui-qin,XIA-Dong~* (Animal Husbandry & Veterinary Research Institute,SAAS,Shanghai 201106,China)
关键词：
Fenvalerate;;Male mice;;Reproductive physiology
摘  要：
To evaluate the effect of fenvalerate on the fertility and physiological mechanism of male mice,the adult male Kunming mice were gastric infused with fenvalerate at a dose of 10 mg/kg BW for 40 days,and the mice sperm quality,testicular ultrastructure,and testosterone and estradiol contents of serum were analyzed.The results showed that there were no significant differences in the sperm counts and the sperm motility between the control and treatment groups,but the fenvalerate treatment significantly increased the spermic abnormality.Transmission electron microscopic observations on the testicular ultrastructure indicated that in the treatment group,the vacuolation appeared on the testicular spermatocyte mitochondria,swelled and vacuolated Sertoli cell mitochondria occurred,the lysosome increased,and the endoplasmic reticulum expanded evidently.The testosterone and estradiol contents of serum in the treatment group were significantly higher than those in the control group respectively at 0.01 and 0.05 levels.It was concluded that gastric infusion of fenvalerate at a dose of 10 mg/kg BW for a long term could disturb the testosterone and estradiol secretion,influence the spermatogenesis, and thus reduce the fertility of male mice.

相似文章

导出引用
计量
文章访问数: 7
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊

友情链接Friendly link
农业信息研究所Agricultural information institute 农业智能知识服务平台Agricultural intelligent knowledge service platform 农业学术服务平台Agricultural Knowledge Service System 中国知网CNKI 维普网VIP 万方WANFANG DATA
联系我们Contact us

电话Tell：010-82109652-808

邮箱E-mail：agrijournal@caas.cn

服务Service
关于我们About us 意见建议Opinions and suggest
版权说明Copyright
单位：中国农业科学院农业信息研究所 中国农学会 © 2017中国农业科学院农业信息研究所 ICP备案号：京ICP备09089781号-46