中国农业科学院农业信息研究所 中国农学会
Agricultural Information Institute of CAAS China Association of Agricultural Science Societies
En
Ch
中国农业科学院农业信息研究所 中国农学会 主办

AI检索

订阅

返回顶部
当前位置: 首页 > 文章 > 新鱼腥草素钠对雏鸡免疫应答的影响 南京农业大学学报 2008,31 (3) 121-124
Position: Home > Articles > Effects of sodium new houtluyfonate on chicken immune response Journal of Nanjing Agricultural University 2008,31 (3) 121-124

新鱼腥草素钠对雏鸡免疫应答的影响

作  者：
朱善元;王健;蒋春茂
单  位：
江苏畜牧兽医职业技术学院
关键词：
新鱼腥草素钠;雏鸡;免疫应答;拮抗
摘  要：
试验Ⅰ:将180羽11日龄非免疫健康三黄鸡随机分为5组。第Ⅰ~Ⅲ组分别注射高、中、低剂量(4、2、1 mg.kg-1)的新鱼腥草素钠(sodium new houtluyfonate,SNH)注射液;Ⅳ组和Ⅴ组分别为白细胞介素2(IL-2)和生理盐水对照。所有动物于14日龄以新城疫病毒(NDV)LaSota株弱毒活疫苗滴鼻进行第1次免疫,2周后加强免疫1次。于第1次免疫后的7、14、21、28、35和42 d测定各组动物的抗NDV血凝抑制抗体水平以及外周血CD4+/CD8+淋巴细胞比值。结果表明,SNH能显著提高鸡体抗NDV抗体水平和外周血CD4+/CD8+淋巴细胞比值(P<0.05),并以中等剂量(2 mg.kg-1)效果最为明显。试验Ⅱ:将72羽7日龄非免疫健康三黄鸡随机分成3组,第Ⅰ组口服氟苯尼考(Florfeni-col,1.2 g.kg-1)并配合肌肉注射SNH(2 mg.kg-1);同时设氟苯尼考(Ⅱ组)和生理盐水(Ⅲ组)对照。各组于14日龄以NDV LaSota株弱毒活疫苗进行第1次免疫,2周后进行第2次免疫;于首免后7、14、21和28 d测定各组动物的抗NDV血凝抑制抗体水平。结果表明,中剂量的SNH对氟苯尼考引起的雏鸡免疫抑制具有一定的拮抗作用。结论:SNH注射液对雏鸡体液免疫和细胞免疫具有明显的增强功能,并能拮抗某些药物引致的免疫抑制作用。
译  名：
Effects of sodium new houtluyfonate on chicken immune response
作  者：
ZHU Shan-yuan,WANG Jian,JIANG Chun-mao(Jiangsu Animal Husbandry and Veterinary College,Taizhou 225300,China)
关键词：
sodium new houtluyfonate(SNH);chicken;immune response;antagonism
摘  要：
Experiment Ⅰ:One hundred and eighty healthy eleven-day-old Sanhuang chickens were assigned to five groups.The 1st to 3rd three groups were tested with different doses(4,2 and 1 mg·kg-1)of sodium new houtluyfonate(SNH)respectively and the 4th group was treated with interleukin 2(IL-2),with the 5th group only injected with normal saline water as control.All the animals were then immunized with the LaSota live vaccine against Newcastle disease virus(NDV)for two times with 14 days interval.On the 7th,14th,21st,28th,35th and 42nd day after the first immunization,the antibody specific to NDV and the ratio of CD4+/CD8+ peripheral lymphocyte was determined,and the data showed that SNH could induce a better antibody response to NDV and increase the ratio of CD4+/CD8+ peripheral lymphocyte.In addition,the effects of different levels of SNH were dissimilar on improving immune response,while the optimistic level was 2 mg·kg-1.Experiment Ⅱ:To determine the effects of SNH on chicken humoral immune response in immunosuppression,72 healthy seven-day-old Sanhuang chicks were assigned to 3 groups.Florfenicol and middle dose(2 mg·kg-1)of SNH were treated in the 1st group,while the 2nd group was orally administered with Florfenicol and the 3rd group was only injected with normal saline water as control.All the animals were vaccinated with the LaSota live vaccine against NDV for two times with 14 days interval.On the 7th,14th,21st and 28th day after the first treatment,the antibody specific to NDV was determined.The data revealed that SNH could antagonise the immunosuppression of Florfenicol on chicken.

相似文章

导出引用
计量
文章访问数: 6
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊

友情链接Friendly link
农业信息研究所Agricultural information institute 农业智能知识服务平台Agricultural intelligent knowledge service platform 农业学术服务平台Agricultural Knowledge Service System 中国知网CNKI 维普网VIP 万方WANFANG DATA
联系我们Contact us

电话Tell：010-82109652-808

邮箱E-mail：agrijournal@caas.cn

服务Service
关于我们About us 意见建议Opinions and suggest
版权说明Copyright
单位：中国农业科学院农业信息研究所 中国农学会 © 2017中国农业科学院农业信息研究所 ICP备案号：京ICP备09089781号-46