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当前位置: 首页 > 文章 > 茶油对兔血脂及动脉粥样硬化的影响 食品科学 2011,32 (7) 289-292
Position: Home > Articles > Effect of Tea-seed Oil on Serum Lipid Level and Atherosclerosis Formation in Rabbits FOOD SCIENCE 2011,32 (7) 289-292

茶油对兔血脂及动脉粥样硬化的影响

作  者：
尹岭;张笑明;李莉;赵秀梅
单  位：
解放军总医院医学信息情报研究所
关键词：
茶油;脂肪肝;动脉粥样硬化;血脂
摘  要：
目的:研究茶油对血脂水平和动脉粥样硬化(AS)形成的影响。方法:32只新西兰大白兔,随机分为4组:对照组(饲喂普通饲料)和3个实验油组(分别饲喂添加茶油、花生油或橄榄油的高脂饲料),各饲喂两个月。在实验前、实验1个月和实验2个月时检测血脂。实验结束时,处死动物,取主动脉、心脏和肝脏标本,做病理组织切片,观察组织形态学的变化,用图像分析软件测量血管粥样变化的程度。结果:喂高脂饲料的3组大白兔的血脂水平均明显高于普通饲料对照组(P<0.01)。茶油组甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)均较花生油组低,但统计学均无显著性差异(P>0.05)。喂高脂饲料实验组的大白兔主动脉、冠状动脉都有不同程度的动脉硬化。花生油组主动脉血管内膜增生最为明显,形成的动脉粥样斑块最大,主动脉狭窄最严重处占到血管的35%～70%,而茶油组和橄榄油组主动脉血管内膜增生较花生油组低,动脉硬化程度轻,主动脉狭窄最严重处只占整个血管的5%～15%。花生油组的肝细胞空泡样改变明显,呈中度脂肪肝病理改变;而茶油组和橄榄油组肝细胞空泡样改变很轻。结论:茶油对高脂饲料诱发的肝脂肪变性和动脉粥样硬化的形成有抑制作用,其作用效果与橄榄油相比无显著差异。
译  名：
Effect of Tea-seed Oil on Serum Lipid Level and Atherosclerosis Formation in Rabbits
作  者：
YIN Ling,ZHANG Xiao-ming,LI Li,ZHAO Xiu-mei(Institute of Medical Information,Chinese PLA General Hospital,Beijing 100853,China)
关键词：
tea-seed oil;fatty liver;atherosclerosis;serum lipid
摘  要：
Objective:To investigate the effect of tea-seed oil on serum lipid metabolism and atherosclerosis(AS) formation.Methods:Totally 32 New Zealand rabbits were randomly divided into four groups.The rabbits in the control group were fed with normal diet and those in other three groups were fed with three kinds of high cholesterol diets containing tea-seed oil,peanut oil and olive oil,respectively,for 2 consecutive months.The serum lipid in each group was measured at 0,1 and 2 months.At the end of the experiment,all animals were sacrificed and the aorta,heart and liver were harvested for histological examination.The morphological change was observed and the atherosclerosis status was measured by using Image-pro plus software.Results:The serum lipid levels in three experiment groups were significantly higher(P<0.01) than that in the control group.The levels of triglycerides(TG),cholesterol(TC) and low-density lipoprotein(LDL) in the tea-seed oil group were lower than those in the peanut oil group,but there was no significant difference(P>0.05) between these indices.Morphological observations revealed atherosclerosis formation in coronary artery and aorta in the three experiment groups.The aortic intimal hyperplasia and atherosclerotic plaque in the peanut oil group were larger than those in the tea-seed oil and olive oil group.The aortic stenosis rate in the peanut oil group was 35%-70%,whereas only 5%-15% in the tea-seed oil group and olive oil group.In addition,the most serious hepatic steatosis was observed in the peanut oil group.The vacuolar change in liver cells clearly showed a pathological feature of moderate fatty liver,but a slight change in pathological feature observed for the tea oil and olive oil groups.Conclusion:Tea-seed oil can inhibit therosclerosis and hepatic steatosis induced by high fat diet,which displays the same pharmaceutical effect as olive oil.

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