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当前位置: 首页 > 文章 > 异甘草素纳米制剂的制备及其性质分析 黑龙江畜牧兽医 2020 (13) 128-131
Position: Home > Articles > Preparation and evaluation of isoliquiritigenin nanoparticles Heilongjiang Animal Science and Veterinary Medicine 2020 (13) 128-131

异甘草素纳米制剂的制备及其性质分析

作  者：
张忠斌;李艳华;沈洪宽;伍哲霖;郑思迪;马金鑫;丁文雅
单  位：
佳木斯市食品药品检验检测中心;东北农业大学动物医学学院;广西中医药大学
关键词：
异甘草素;壳聚糖环糊精聚合物;纳米制剂;性质分析;体外释放
摘  要：
为了制备能增加药物溶解度、提高药物生物利用度、增强抗菌效果的异甘草素纳米新制剂,并对制剂的性质进行分析,试验以壳聚糖-环糊精聚合物为载体制备异甘草素纳米制剂,并对其性质进行表征,利用NANOSAQLA纳米粒度测定仪测定异甘草素纳米制剂的粒径和Zeta电位,利用紫外-可见分光光度法测定其包封率,重量法测定纳米制剂载药量,透射电镜法观察纳米制剂形态,动态透析法测定纳米制剂的体外释放行为,并考察纳米制剂分别在4℃和室温下的稳定性。结果表明:可以用壳聚糖-环糊精聚合物制备异甘草素纳米制剂,异甘草素纳米制剂的粒径为(219.91±1.23)nm,Zeta电位为(41.43±0.63)mV,包封率为(78.07±0.93)%,载药量为(4.460±0.230)%,纳米制剂形态为球形,且粒径分布较为均匀,其在4℃和室温下均较为稳定,且具有明显缓释效果。说明试验制备的异甘草素纳米制剂具有良好的性质。
译  名：
Preparation and evaluation of isoliquiritigenin nanoparticles
作  者：
ZHANG Zhongbin;LI Yanhua;SHEN Hongkuan;WU Zhelin;ZHENG Sidi;MA Jinxin;DING Wenya;Guangxi University of Chinese Medicine;College of Veterinary Medicine, Northeast Agricultural University;Jiamusi food and drug inspection and Testing Center;
关键词：
isoliquiritigenin;;chitosan grafted β-cyclodextrin;;nanoparticles;;property analysis;;in vitro release
摘  要：
In order to study and prepare a new nanometer preparation of isoliquiritigenin which can increase the solubility of drugs, improve the bioavailability of drugs and enhance the antibacterial effect, the characterizations of the preparation were analyzed. In this experiment, chitosan grafted β-cyclodextrin was used as the carrier to prepare isoliquiritigenin nano-preparation, and its properties were characterized. The particle size and Zeta potential of isoliquiritigenin nano-preparation were determined by NANOSAQLA nano laser particle size analyzer. The encapsulation rate was determined by ultraviolet-visible spectrophotometry. The loading capacity of nanoparticle preparation was determined by gravimetric method. The morphology of the nanoparticle preparation was observed by transmission electron microscopy. The release behavior of nanomaterials in vitro was determined by dialysis method, and the stability of nanomaterials at 4 ℃ and room temperature was investigated. The results showed that the mean diameters and Zeta potential of diameters of the isoliquiritigenin nanoparticle was(219.91±1.23) nm, Zeta potential was(41.43±0.63) mV, the encapsulation rate was(78.07±0.93)%, the drug loading was(4.460±0.230)%, the shape of the nanoparticle preparation was spherical, the particle size distribution was relatively uniform, it was relatively stable at 4 ℃ and room temperature, and it had obvious slow-release effect. It indicated that the nanoparticle preparation of isoliquiritigenin had good properties.

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