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当前位置: 首页 > 文章 > 复方山楂颗粒的制备及质量控制 东北农业科学 2019 (6) 102-106
Position: Home > Articles > Studies on Development and Quality Control of Compound Hawthorn Granules Journal of Northeast Agricultural Sciences 2019 (6) 102-106

复方山楂颗粒的制备及质量控制

作  者：
李向群;徐冲;刘子明;隋昌海
单  位：
吉林工程职业学院生物工程学院
关键词：
山楂;决明子;湿法制粒;质量控制
摘  要：
本次试验在山楂和决明子(3∶1)为原材料的基础上加入辅料,并采用湿法制粒的制备工艺制成颗粒从而方便携带,通过单因素法确定最佳辅料种类及配比,采用正交试验得出最佳制备工艺,最后对其进行质量检查。结果表明:选用药用糊精为稀释剂,浸膏粉与药用糊精比例为1∶2,选择70%乙醇为润湿剂,浸膏粉与70%乙醇的比例为1∶1.5,干燥温度为50℃,干燥时间为40 min,所制得的颗粒最佳,颗粒质量标准符合药典规定。
译  名：
Studies on Development and Quality Control of Compound Hawthorn Granules
作  者：
LI Xiangqun;XU Chong;LIU Ziming;SUI Changhai;College of Biological Engineering, Jilin Engineering Professional College;
关键词：
Crataegus pinnatifida Bunge;;Semen Cassiae;;Wet granulation;;Quality control
摘  要：
In this experiment,Crataegus pinnatifida Bunge and Semen cassiae(3∶1) as raw material were added with accessories, and wet granulation was used to prepare granules for easy carrying. The optimum type and proportion of excipients were determined by single factor method, and the optimum preparation process was obtained by orthogonal experiment. Finally, the quality of the granules was checked. The results showed that the diluent was used as medical dextrin and the ratio of extract powder and medical dextrin was 1∶2. The wetting agent was 70% ethanol,the ratio of extract powder and 70% ethanol was 1∶1.5. The drying temperature was 50°C, and the drying time was40 min. The prepared granules had the best effect and the quality standard of granules met the requirements of pharmacopoeia.

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