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当前位置: 首页 > 文章 > 碱提醇沉黑木耳多糖体外和体内降血脂功能 食品科学 2017,38 (1) 232-237
Position: Home > Articles > In Vitro and in Vivo Hypolipidemic Effect of Auricularia auricular Polysaccharides FOOD SCIENCE 2017,38 (1) 232-237

碱提醇沉黑木耳多糖体外和体内降血脂功能

作  者：
于美汇;赵鑫;尹红力;刘冉;王振宇
单  位：
东北林业大学林学院;通化师范学院制药与食品科学学院;哈尔滨工业大学化工与化学学院;中国农业科学院农产品加工研究所主食加工技术研究院;聊城大学农学院
关键词：
黑木耳多糖;胆酸盐;降血脂;卵磷脂胆固醇酰基转移酶
摘  要：
目的:探讨黑木耳多糖体内和体外降血脂功能。方法:采用离体实验模拟人体胃和肠道的p H值环境,探讨不同溶剂提取黑木耳多糖及其不同醇沉片段对胆酸盐的结合能力,评价其体外降血脂功能。以高脂饲料喂养小鼠建立高血脂模型,通过黑木耳多糖的治疗,比较治疗前后小鼠体质量、血清总胆固醇(total cholesterol,TC)、总甘油三酯(triglyceride,TG)、低密度总胆固醇(low density lipoprotein cholesterol,LDL-C)、高密度总胆固醇(high density lipoprotein cholesterol,HDL-C)含量及其关键酶卵磷脂胆固醇酰基转移酶(lecithin cholesterol acyltransferase,LCAT)、肝脂酶(liver lipase,HL)和脂蛋白脂酶(lipoprotein lipase,LPL)的活性,研究碱提黑木耳多糖对高血脂模型小鼠的降血脂作用。结果:体外降血脂实验结果表明:3种不同的黑木耳多糖样品中,碱提黑木耳多糖的结合效果最好;不同体积分数乙醇醇沉黑木耳多糖片段的结合效果比较显示,70%醇沉片段结合胆酸盐效果最好。体内降血脂实验结果发现,碱提+70%醇沉黑木耳多糖能够缓解小鼠体质量的增长,显著缓解TC、TG和LDL-C含量的下降,显著提升HDL-C水平,控制LCAT含量、HL和LPL活性的降低。结论:碱提+70%醇沉黑木耳多糖具有降血脂功能。
译  名：
In Vitro and in Vivo Hypolipidemic Effect of Auricularia auricular Polysaccharides
作  者：
YU Meihui;ZHAO Xin;YIN Hongli;LIU Ran;WANG Zhenyu;School of Forestry, Northeast Forestry University;School of Pharmaceutics and Food Science, Tonghua Normal University;Institute of Staple Food Processing Technology, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences;College of Agriculture, Liaocheng University;School of Chemistry and Chemical Engineering, Harbin Institute of Technology;
关键词：
Auricularia auricular polysaccharides;;cholate;;hypolipidemic;;lecithin cholesterol acyltransferase(LCAT)
摘  要：
Objective: To explore the hypolipidemic effect of Auricularia auricular polysaccharides in vitro and in vivo. Methods: Under simulated human gastric and intestinal p H conditions, the cholate binding capacity and in vitrohypolipidemic effect of Auricularia auricular polysaccharides extracted with different solvents and their alcohol-precipitated fractions. To evaluate the hypolipidemic effect of alkali-soluble polysaccharides from Auricularia auricular, the changes in body weight, serum total cholesterol(TC), total triglyceride(TG), low density lipoprotein cholesterol(LDL-C), high density total cholesterol(HDL-C) and the activity of lecithin cholesterol acyltransferase(LCAT), which is the key enzyme involved in HDL-C metabolism, and hepatic lipase(HL) and lipoprotein lipase(LPL) activities in hyperlipidemic rat models induced by high-fat feeding were detected before and after oral administration of the polysaccharides. Results: Among three different solvent soluble polysaccharides from Auricularia auricular, the alkali-soluble polysaccharides had the strongest cholate binding capacity, which was most ascribed to the 70% ethanol-precipitated fraction. In addition, this polysaccharide fraction could significantly alleviate body weight gain, slow down the increase in serum TC, TG and LDL-C, increase LDL-C significantly, and block the decrease in LCAT, HL and LPL activities. Conclusion: The 70% ethanol-precipitated fraction of alkali-soluble polysaccharides from Auricularia auricular had a significant hypolipidemic effect in experimentally induced hyperlipidemic rats.

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