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当前位置: 首页 > 文章 > 钧端螺旋体病肾脏病理研究——Ⅱ.实验性豚鼠钩端螺旋体病肾脏病理形态观察 华中农业大学学报 1983 (3) 51-54+98
Position: Home > Articles > PATHOLOGIC STUDIES ON KINDEY IN LEPTOSPIROSIS——Ⅱ.OBSERVATION ON RENAL PATHOMORPHOLOGY IN EXPERIMENTAL LEPTOSPIROSIS OF GUINEA PIGS Journal of Huazhong Agricultural University 1983 (3) 51-54+98

钧端螺旋体病肾脏病理研究——Ⅱ.实验性豚鼠钩端螺旋体病肾脏病理形态观察

作  者：
秦礼让;雷健保;周诗其
单  位：
华中农学院畜牧兽医系
摘  要：
无论是在自然或实验性猪的钩体病例,肾脏的病理变化常受到重视,并被广泛地报道为:“间质性肾炎”,至于肾小球的变化,一般涉及甚少或被认为缺乏特征的变化。本研究I对自然感染若干血清型钩体的猪肾脏病变的研究中,发现除了间质炎症的特征外,尚普遍有肾小球系膜细胞增生的明显变化。自然病例的这种表现似值得作出进一步探讨。基于这些设想,进行如下的研究:
译  名：
PATHOLOGIC STUDIES ON KINDEY IN LEPTOSPIROSIS——Ⅱ.OBSERVATION ON RENAL PATHOMORPHOLOGY IN EXPERIMENTAL LEPTOSPIROSIS OF GUINEA PIGS
作  者：
Qin Li-rang
摘  要：
Twenty one guinea pigs were divided into four groups. Three groups ofthem were experimently infected with L.pomona, L. romania and L. icterohem-morrhagiae respectively. From 12 days to 85 days after infection, these infectedguinea pigs with the control group were autopsied. They were examined forgross and microscopic pathological changes. Renal samples were fixed in 10% bu-ffered formalin and Carnoy, and embeded as usual. six μm section were stainedwith H.E., Levaditi and periodic acid Schiff. Guinea pigs infected with L. ictero-hemmorrhagiae had more marked pathological changes, such as icterohemorrhag-ic lesions in acute stage. But in their later stage there were showed interstitialnephritis and mesangial proliferation. The guinea pigs infected with two otherserotypes were also showed interstitial nephritis and glomerular mesangial cellproliferation. These lesions were similar to those of pig's natural cases whichreported previously. These results would indicate that glomerular lmesanginalcell proliferation is rather common and important in both natural and experi-mental cases of leptospirosis.

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