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Position: Home > Articles > Optimization of Lubricant Typye and Amount in Seaweed Polysaccharide-Inulin Effervescent Tablets by Response Surface Methodology FOOD SCIENCE 2012,33 (12) 93-96

响应面法优化海藻多糖菊粉泡腾片润滑剂种类及添加量

作  者:
蒲洋;冯大伟;包焕玲;秦松;衣悦涛
单  位:
中国科学院海洋研究所;山东东方海洋科技股份有限公司;中国科学院大学;中国科学院烟台海岸带研究所中国科学院大学鲁东大学农学院;中国科学院烟台海岸带研究所
关键词:
泡腾片;配方优化;菊粉;有机富硒海藻多糖
摘  要:
以有机富硒海藻多糖、菊粉原料,采用无水乙醇酸碱两相制粒法,制备富硒海藻多糖菊粉泡腾片。通过3因素3水平的Box-Behnken试验设计及响应面试验优化硬脂酸镁、十二烷基硫酸钠、微粉硅胶润滑剂在配方中添加量;最优配方为硬脂酸镁添加量0.70%、十二烷基硫酸钠添加量2.60%、微粉硅胶添加量0.90%。对最终产品进行质量分析,结果表明:所得产品制粒、压片效果好,各项指标均符合《中华人民共和国药典》相关规定。
译  名:
Optimization of Lubricant Typye and Amount in Seaweed Polysaccharide-Inulin Effervescent Tablets by Response Surface Methodology
作  者:
PU Yang1,2,FENG Da-wei1,BAO Huan-ling3,QIN Song1,YI Yue-tao1,(1.Yantai Institute of Coastal Zone Research,Chinese Academy of Sciences,Yantai 264003,China;2.Graduate University of Chinese Academy of Sciences,Beijing 100049,China;3.Shandong Oriental Ocean Sci-tech Co.Ltd.,Yantai 264003,China)
关键词:
effervescent tablets;optimum formulation;inulin;organic selenium-enriched seaweed polysaccharide
摘  要:
Effervescent tablets were prepared from organic selenium-enriched seaweed polysaccharides and inulin by absolute alcohol-acid-base two-phase granulation method.Using response surface methodology based on a three-variable,three-level central composite design,the amounts of the added lubricants sodium dodecylsulfate,magnesium stearate,and silica powder in effervescent tablet formulation were optimized to be 0.70%,2.60% and 0.90%,respectivley.All the quality indexes fhe prepared effervescent tablets complied with the requirements of the Chinese Pharmacopoeia.

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