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Position: Home > Articles > Inhibition of Tumor Cell Proliferation by a Neutral Triterpenoid Fraction from Ganoderma lucidum Acta Edulis Fungi 2010,17 (1) 60-64

灵芝中性三萜类成分的抗肿瘤作用

作  者:
唐庆九;季哲;郝瑞霞;刘艳芳;杨焱;张劲松
单  位:
农业部应用真菌资源与利用重点开放实验室;上海市农业科学院天然药用资源研究开发中心;上海市农业遗传育种重点开放实验室;国家食用菌工程技术研究中心;上海市农业科学院食用菌研究所
关键词:
灵芝;灵芝三萜;抗肿瘤;细胞凋亡
摘  要:
从灵芝(Ganoderma lucidum)子实体中分离纯化得到中性三萜部分,经HPLC检测发现主要有8个峰,与灵芝三萜酸性部分的峰基本不重叠。灵芝中性三萜部分对多种肿瘤细胞的增殖有抑制作用,并观察到可诱导肠癌SW620细胞凋亡。
译  名:
Inhibition of Tumor Cell Proliferation by a Neutral Triterpenoid Fraction from Ganoderma lucidum
作  者:
TANG Qingjiu,JI Zhe,HAO Ruixia,LIU Yanfang,YANG Yan,ZHANG Jinsong National Engineering Research Center of Edible Fungi; Key Laboratory of Applied Mycological Resources and Utilization,Ministry of Agriculture,People's Republic of China; Key Laboratory of Agricultural Genetics and Breeding of Shanghai; Research Center of Natural Medicinal Resources,Institute of Edible Fungi,Shanghai Academy of Agricultural Sciences,Shanghai 201106,China
关键词:
Ganoderma lucidum; antitumor; neutral triterpene; apoptosis
摘  要:
A neutral triterpene fraction (NTF) isolated from Ganoderma lucidum fruit bodies was shown by HPLC to consist of eight major components which differed from the constituents in an acidic triterpenoid fraction (ATF). The NTF inhibited the proliferation of several tumor cell lines and induced apoptotic bodies in SW620 tumor cells.

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