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当前位置: 首页 > 文章 > 日粮核苷酸对机体炎症抗炎症平衡体系的影响 中国兽医科学 2006,36 (1) 66-69
Position: Home > Articles > Effects of dietary nucleotides on inflammatory and anti-inflammatory balance Chinese Veterinary Science 2006,36 (1) 66-69

日粮核苷酸对机体炎症抗炎症平衡体系的影响

作  者：
李石营;施用晖;乐国伟
单  位：
江南大学食品学院食品科学与安全教育部重点实验室
关键词：
核苷酸;CpG DNA;LPS;炎症;抗炎症;平衡
摘  要：
为探讨日粮核苷酸对小鼠炎症/抗炎症平衡体系的作用,用CpG DNA和脂多糖(LPS)刺激小鼠构建炎症反应模型,观察分别饲喂无核苷酸(NF)日粮和核苷酸(NT)日粮小鼠的炎性细胞因子IL-1、IFN-γ、抗炎性细胞因子IL-10水平和小肠髓过氧化物酶(MPO)活性变化。结果显示,在刺激后第4 h时,NT组小鼠的IL-1(P<0.05)、IFN-γ(P<0.01)和小肠MPO(P<0.01)明显低于NF组,IL-10(P>0.05)高于NF组;刺激后第18 h时,NT与NF组的IL-1(P<0.01)、IFN-γ(P<0.01)I、L-10(P>0.05)和MPO(P<0.01)均较刺激后第4 h有所降低,NT组的IL-1(P>0.05)、IFN-γ(P<0.05)和小肠MPO(P<0.05)仍低于NF组,IL-10(P>0.05)仍高于NF组。表明,日粮核苷酸对CpG DNA或LPS所诱导的炎症反应有明显的抑制作用,有助于维持机体炎症/抗炎症平衡,保护机体免受炎症损伤。
译  名：
Effects of dietary nucleotides on inflammatory and anti-inflammatory balance
作  者：
LI Shi-ying,SHI Yong-hui,LE Guo-wei(Key Laboratory of Food Science and Safety,Ministry of Education/ Southern Yangtze University,Wuxi 214036,China)
关键词：
nucleotides;CpG DNA;LPS;inflammation;anti-inflammation;balance
摘  要：
The aim of this study was to evaluate effect of dietary nucleotides on inflammation and anti-inflammation homeostasis.Mice were administrated with nucleotide-free(NF) or nucleotide-supplemented(NT) diet,and inflammatory cytokine IL-1,IFN-γ,anti-inflammatory cytokine IL-10 and intestinal myeloperoxidase(MPO) were determined at 4th and 18th h after stimulation with CpG DNA and LPS.Production of IL-1(P<0.05),IFN-γ(P<0.01) and activity of MPO(P<0.01) decreased,whereas production of IL-10(P>0.05)increased with nucleotides supplement at 4th h after stimulation.At 18th h after stimulation,production of IL-1(P<0.01),IFNγ(P<0.01),IL-10(P>0.05) and activity of MPO(P<0.01) were lower than that at 4th h.Production of IL-1(P<0.05),IFN-γ(P<0.01) and activity of MPO((P<0.01)) in Groups NT were still lower than that in Groups NF,and production of IL-10(P>0.05) was still higher than that in Groups NF.The results indicated dietary nucleotides can depress inflammation induced by CpG DNA or LPS,maintain inflammatory and anti-inflammatory balance and protect animals from injury.

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