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当前位置: 首页 > 文章 > 冷榨葡萄籽饼粕超微粉对衰老小鼠内脏抗氧化功能的影响 食品科学 2013,34 (17) 299-304
Position: Home > Articles > Effect of Cold-pressed Grape Seed Superfine Powder (CP-GSSP) on Antioxidative Functions in Aging Mouse Viscera FOOD SCIENCE 2013,34 (17) 299-304

冷榨葡萄籽饼粕超微粉对衰老小鼠内脏抗氧化功能的影响

作  者：
刘霞;杨继红;王海瑞;隋银强;李华;王华
单  位：
西北农林科技大学葡萄酒学院;西安新药评价中心
关键词：
冷榨;葡萄籽;超微粉;内脏;抗氧化
摘  要：
目的:研究酿酒副产物葡萄籽冷榨提油后饼粕超微粉对衰老小鼠心脏、肾脏和肝脏的抗氧化功能的影响。方法:60只小鼠随机分为冷榨葡萄籽饼粕超微粉(CP-GSSP)低、中、高剂量组(323、646、1938mg/(kg·d))、VE组(25mg/(kg·d))、衰老模型组和空白组。除空白组腹腔注射等体积生理盐水外,其他各组腹腔注射D-半乳糖构建亚急性衰老模型,同时剂量组灌胃给予CP-GSSP,VE组给予油溶性VE,模型组和空白组均给予同体积食用油。持续45d后,测定心脏、肾脏和肝脏中丙二醛(MDA)含量、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)的活力。结果:形态水平:CP-GSSP可以抵抗由D-半乳糖所致的衰老表征的出现并且对内脏无不良影响。生化水平:CP-GSSP能够显著降低小鼠心脏、肾脏和肝脏中脂质过氧化物MDA的含量,提高抗氧化酶SOD和GSH-Px的活力。结论:CP-GSSP具有显著抑制衰老小鼠体内脂质过氧化的作用、能明显提高内源性抗氧化酶活性并且无毒副作用,表明其具有较好的抗氧化、抗衰老作用。
译  名：
Effect of Cold-pressed Grape Seed Superfine Powder (CP-GSSP) on Antioxidative Functions in Aging Mouse Viscera
作  者：
LIU Xia;YANG Ji-hong;WANG Hai-rui;SUI Yin-qiang;LI Hua;WANG Hua;College of Enology, Northwest A & F University;Shaanxi Engineering Research Center for Viti-viniculture;Viti-viniculture Experiment Station (Heyang) of Northwest A & F University;Xi'an New Drug Evaluation and Research Center;
关键词：
cold-pressed grape seeds;;superfine powder;;viscera;;antioxidation
摘  要：
Objective: To explore the effect of cold-pressed grape seed superfine powder(CP-GSSP) on visceral anti-oxidative function in aging mice. Methods: Sixty mice were randomly divided into CP-GSSP low, medium and high dose groups(323, 646, 1938 mg/(kg · d)), VE group(25 mg/(kg · d)), aging model group and normal control group. The mice in the normal control group were intraperitoneally injected with physiological saline, whereas, other groups were intraperitoneally injected with D-galactose to establish aging mouse model. Along with intraperitoneal injection, the mice from the CP-GSSP groups, VE group, aging model group and normal control group were intragastrically administered with CP-GSSP at various doses, VE, edible oil and edible oil, respectively. Forty-five days later, the content of MDA, and the activities of SOD and GSH-Px in heart, kidney and liver were detected. Results: CP-GSSP resisted the aging performance caused by D-galactose without causing adverse effects in viscera, and significantly reduced the content of MDA, and improved the activities of SOD and GSH-Px in heart, kidney and liver. Conclusion: CP-GSSP can inhibit lipid peroxidation and improve the activity of endogenous antioxidases in aging mice. Therefore, it has a good antioxidant and anti-aging effect.

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