中国农业科学院农业信息研究所 中国农学会
Agricultural Information Institute of CAAS China Association of Agricultural Science Societies
En
Ch
中国农业科学院农业信息研究所 中国农学会 主办

AI检索

订阅

返回顶部
当前位置: 首页 > 文章 > 肝片形吸虫与鸡蛔虫对某些神经递质及药物的反应的比较 畜牧兽医学报 1984,15 (2) 64-72
Position: Home > Articles > A COMPARISON OF RESPONSES BETWEEN F.HEPATICA,THE LIVER FLUKE,AND A.GALLI,THE CHICKEN ROUNDWORM,TO SOME NEUROTRANSMITTERS AND DRUGS Chinese Journal of Animal and Veterinary Sciences 1984,15 (2) 64-72

肝片形吸虫与鸡蛔虫对某些神经递质及药物的反应的比较

作  者：
戎耀方;沈丽琳;赵桂芳
单  位：
南京农学院畜牧兽医系药理教研组
摘  要：
本文以肝片形吸虫和鸡蛔虫作为扁形动物和线形动物的代表,在离体器官测定仪上通过机械功能的变化记录了它们对数种神经递质和药物的神经肌肉反应,并对这些反应进行了比较,这种测定方法比过去所用的方法准确、灵敏。肝片形吸虫和鸡蛔虫对神经递质和药物的反应基本上是不同的。胆碱酯类(乙酰胆碱、氨甲酰胆碱和乙酰甲胆碱)及毒扁豆碱对肝片形吸虫呈抑制作用而对鸡蛔虫则呈兴奋作用。硫酸阿托品能完全阻断胆碱酯类对肝片形吸虫的抑制作用,但只能部分阻断胆碱酯类对鸡蛔虫的兴奋作用。5-HT 对肝片形吸虫有强大的兴奋作用而对鸡蛔虫则表现抑制作用。盐酸肾上腺素对肝片形吸虫呈抑制作用,而对鸡蛔虫则表现兴奋作用。酚妥拉明对这两种虫均表现兴奋作用,且不具有阻断肾上腺素对肝片形吸虫的作用,原因可能与 LSD 相似。文中对这两种虫的受体性质及其在筛选驱虫药时作为实验模型的价值进行了讨论。
译  名：
A COMPARISON OF RESPONSES BETWEEN F.HEPATICA,THE LIVER FLUKE,AND A.GALLI,THE CHICKEN ROUNDWORM,TO SOME NEUROTRANSMITTERS AND DRUGS
作  者：
RONG YAO-FANG Y.F.JUNG SHEN LI-LIN ZHAO GUI-FANG (Section of Pharmacology,Department of Animal Husbandry and Veterinary Science,Nanjing Agricultural College,Nanjing)
摘  要：
The liver fluke and chicken roundworm were used as representatives of platyhelminthes and nemat- helminthes respectively in this study to test the responses to some neurotransmitters and drugs.The res- ponses of these two parasites wererecorded and compared through mechanical functional changes by means of an electrical recording apparatus for experiment with isolated tissues.It is more reliable and sensitive for measuring the effect of drugs on parasites.It was found that the responses of liver fluke to drugs were quite different from those of chicken roundworm to the same drugs.The rhythmical activity of the liver fluke was inhibited and those of chicken roundworm was stimulated by choline esters (acetylcholine, carbacholine and acetyl-β-methylcholine)and eserine.Atropine was found to cause complete block on liver fluke and only partial block on chicken roundworm to the effect of choline esters.5-Hydroxytryp- tamine produced a potent stimulant effect on liver fluke and a depressant effect on chicken roundworm. Epinephrine hydroehlgride possesed inhibitory effect on liver fluke,but weaker stimulatory effect on chi- cken roundworm.α-Adrenergic blocker phentolamine was found to be a stimulant on both liver fluke and chicken roundworm and not to be an adrenergic blocker on liver fluke.Apparently this blocker was simi- lar in effect on liver fluke to another a-blocker lysergic acid diethylamide (LSD) and may be art ago- nist on 5-HT receptor.The value of both parasites as a testing model for screening*anthelmintics and what possible type of nerve-muscle receptors were existed in both of them are discussed.

相似文章

导出引用
计量
文章访问数: 4
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊

友情链接Friendly link
农业信息研究所Agricultural information institute 农业智能知识服务平台Agricultural intelligent knowledge service platform 农业学术服务平台Agricultural Knowledge Service System 中国知网CNKI 维普网VIP 万方WANFANG DATA
联系我们Contact us

电话Tell：010-82109652-808

邮箱E-mail：agrijournal@caas.cn

服务Service
关于我们About us 意见建议Opinions and suggest
版权说明Copyright
单位：中国农业科学院农业信息研究所 中国农学会 © 2017中国农业科学院农业信息研究所 ICP备案号：京ICP备09089781号-46