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Position: Home > Articles > Protective Effect of Berberine on Serum and Kidney in Experimental Diabetic Rats Food and Nutrition in China 2013,19 (07) 68-70

黄连素对2型糖尿病大鼠血清、肾脏的保护作用

作  者:
赵洪涛;安锦丹;孙健
单  位:
牡丹江医学院
关键词:
黄连素;2型糖尿病;羟自由基
摘  要:
目的:观察黄连素对实验性2型糖尿病大鼠血清、肾脏中羟自由基(.OH)能力的影响。方法:采用小剂量链脲佐菌素加高糖高脂饲料喂养的方法建立Wistar大鼠2型糖尿病模型,成模后给予黄连素0.1g/(kg.d)灌胃治疗8周,检测血清、肾脏羟自由基能力的变化。结果:与糖尿病组相比,黄连素组肾脏、血清中羟自由基能力下降,各观察值均与糖尿病组存在显著性差异(P<0.05)。结论:黄连素可保护大鼠的血清和肾脏,降低羟自由基能力,减少自由基对机体细胞的损伤。
译  名:
Protective Effect of Berberine on Serum and Kidney in Experimental Diabetic Rats
作  者:
ZHAO Hong-tao 1,2,AN Jin-dan 1,SUN Jian 1(1 Mudanjiang Medical College,Mudanjiang 157011,China;2 Key Laboratory of Cancer Prevention and Treatment of Heilongjiang Province,Mudanjiang 157011,China)
关键词:
berberine;type 2 diabetes mellitus;hydroxyl free radical
摘  要:
Objective To observe the changes of.OH in the serum and kidney in the type 2 diabetes mellitus rats treated by berberine.Method The model of type 2 diabetes rats was made by the intravenous injection of a small dose of streptozotocin plus high caloric food.The animals were treated with berberine 0.1g /(kg.d) for 8 weeks.The contents of.OH in the serum and kidney were determined.Resu lt Compared to diabetetic rats,the content of the MDA in the serum and kidney dropped and the activity of SOD enhanced in berberine group.Conc"lusions"Berberine could protect the rats’kidney and serum,which might be related with the mechanism of free radical clearance.

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