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Position: Home > Articles > THE EXPERIMENTAL SYNTHESIS AND APPLICATION OF“JING SONG LING”——A VETERINARY SEDATIVE, ANALGESIC AND MYORELAXANT Scientia Agricultura Sinica 1981,14 (4) 9-16

兽用镇静、镇痛、肌松药“静松灵”的研制和应用

作  者:
赵荣材;张隆山
单  位:
中国农业科学院中兽医研究所
摘  要:
几种甲基取代苯胺噻嗪和苯胺噻唑的合成及其镇痛和催眠作用 1962年德国人合成了一系列取代苯胺噻嗪之后,推荐其代表化合物2-(2.6-二甲基苯胺基)-5.6-二氢-4H-1.3一噻嗪(Xylazine,商品名Rompun,我们简称2.6-二甲基苯胺噻嗪)应用于兽医临床。目前国外已将该药普遍用作各种动物的镇麻剂。
译  名:
THE EXPERIMENTAL SYNTHESIS AND APPLICATION OF“JING SONG LING”——A VETERINARY SEDATIVE, ANALGESIC AND MYORELAXANT
作  者:
Zhao Rong-cai Zhang Long-shan (Institute of Chinese Traditional Veterinary Medecine, Chinese Academy of Agricultural Sciences)
摘  要:
Two compounds with effective sedative, analgesic and myorelaxant actions and with low toxicity, namely 2-(2.6-xylidino-1.3-thiazole) and 2-(2.4-xylidino-1.3-thiazole, commercial name : "Jing Song Ling"), were successfully screened from two "xylidino-1.3-thiazine compounds and four derivatives of xylidino-1.3-thiazole", which had been synthesized in our laboratory. Owing to the sufficient supply of raw materials for the preparation of 2-(2.4-xylidino-1.3-thiazole) over 2-(2.6-xylidino-1.3-thiazole), priority in commercial production and clinical trials should be given to 2-(2.4-xylidino-1.3-thiazole). Clinical experiments of "Jing Song Ling" on domestic as well as on wild animals have proved that it possessed the same efficacy as Rompun, which has been introduced from abroad. The methods of synthesis, potency and toxicity tests as well as results of clinical trials of. "Jing Song Ling" were described and discussed in this paper.

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